Literature DB >> 2475452

The effects of oxygen free radicals on wound healing.

D Foschi1, E Trabucchi, M Musazzi, L Castoldi, D Di Mattia, E Radaelli, M Marazzi, P Franzini, A Berlusconi.   

Abstract

We have examined the effects of oxygen free radicals, generated by xenobiotics administration, ischaemia-reperfusion or sepsis, on the healing of skin or intestinal wounds in rats. We found that 5 days after operation there was a significant decrease in the wound breaking strength in rats treated with phenazine methosulfate, zymosan, ischaemia-reperfusion or retroperitoneal infection. These changes were specifically prevented by administration of superoxide-dismutase (SOD), aprotinin and (in some models) allopurinol. On the contrary, none of these measures was effective when a local trauma caused the decrease in breaking strength. Our results suggest that oxygen free radicals mediate the inhibition of wound healing following ischaemia-reperfusion and sepsis.

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Year:  1988        PMID： 2475452

Source DB:  PubMed          Journal:  Int J Tissue React        ISSN： 0250-0868


  10 in total

1.  Effect of taurine on wound healing.

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2.  Antioxidant status during cutaneous wound healing in immunocompromised rats.

Authors:  Asheesh Gupta; Ram L Singh; Ram Raghubir
Journal:  Mol Cell Biochem       Date:  2002-12       Impact factor: 3.396

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5.  Ultra-low microcurrent in the management of diabetes mellitus, hypertension and chronic wounds: report of twelve cases and discussion of mechanism of action.

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6.  Evaluation of topical tocopherol cream on cutaneous wound healing in streptozotocin-induced diabetic rats.

Authors:  Teoh Seong Lin; Azian Abd Latiff; Noor Aini Abd Hamid; Wan Zurinah Bt Wan Ngah; Musalmah Mazlan
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7.  Vitamin e and the healing of bone fracture: the current state of evidence.

Authors:  Boekhtiar Borhanuddin; Nur Farhana Mohd Fozi; Isa Naina Mohamed
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8.  Postoperative Administration of Alpha-tocopherol Enhances Osseointegration of Stainless Steel Implants: An In Vivo Rat Model.

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Journal:  Sci Rep       Date:  2020-07-22       Impact factor: 4.379

10.  Collagen sponge prolongs taurine release for improved wound healing through inflammation inhibition and proliferation stimulation.

Authors:  Liang Wu; Qianwen Zhang; Yuan Li; Wenxiang Song; Anqi Chen; Jingjing Liu; Xuan Xuan
Journal:  Ann Transl Med       Date:  2021-06
  10 in total

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