| Literature DB >> 2475350 |
F Elinder1, A K Mohammed, B Winblad, P Arhem.
Abstract
In voltage-clamp experiments with the myelinated nerve fibre of Xenopus laevis, 9-amino-1,2,3,4-tetrahydroacridine (THA) decreased both Na+ and K+ currents and shifted the steady state inactivation potential curve in a negative direction. The effects may be described as (a) a decrease of the permeability constant PNa, (b) a modified potential dependence of the inactivating system and (c) a decrease of PK. The Na+ system was affected more than the K+ system.Entities:
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Year: 1989 PMID： 2475350 DOI： 10.1016/0014-2999(89)90272-0
Source DB: PubMed Journal: Eur J Pharmacol ISSN： 0014-2999 Impact factor: 4.432