Literature DB >> 24753450

A platform for controlled dual-drug delivery to the retina: protective effects against light-induced retinal damage in rats.

Nobuhiro Nagai1, Hirokazu Kaji, Hideyuki Onami, Yuki Katsukura, Yumi Ishikawa, Zhaleh Kashkouli Nezhad, Kaori Sampei, Satoru Iwata, Shuntaro Ito, Matsuhiko Nishizawa, Toru Nakazawa, Noriko Osumi, Yukihiko Mashima, Toshiaki Abe.   

Abstract

Controlled transscleral co-delivery of two drugs, edaravone (EDV) and unoprostone (UNO), using a platform that comprises a microfabricated reservoir, controlled-release cover, and drug formulations, which are made of photopolymerized poly(ethyleneglycol) dimethacrylates, shows synergistic retinal neuroprotection against light injury in rats when compared with single-drug-loaded devices. The device would offer a safer therapeutic method than intravitreal injections for retinal disease treatments.
© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  edaravone; poly(ethyleneglycol) dimethacrylate; retina; transscleral drug delivery; unoprostone

Mesh：

Substances：

Year:  2014        PMID： 24753450     DOI： 10.1002/adhm.201400114

Source DB:  PubMed          Journal:  Adv Healthc Mater        ISSN： 2192-2640            Impact factor:   9.933


  7 in total

Review 1.  Recent advances of controlled drug delivery using microfluidic platforms.

Authors:  Sharma T Sanjay; Wan Zhou; Maowei Dou; Hamed Tavakoli; Lei Ma; Feng Xu; XiuJun Li
Journal:  Adv Drug Deliv Rev       Date:  2017-09-15       Impact factor: 15.470

2.  Physicochemical and biological characterization of sustained isopropyl unoprostone-release device made of poly(ethyleneglycol) dimethacrylates.

Authors:  Nobuhiro Nagai; Yasuko Izumida; Yoshimasa Yamazaki; Hirokazu Kaji; Junichi Kawasaki; Matsuhiko Nishizawa; Toshiaki Abe
Journal:  J Mater Sci Mater Med       Date:  2017-05-22       Impact factor: 3.896

3.  Photoreceptor preservation induced by intravitreal controlled delivery of GDNF and GDNF/melatonin in rhodopsin knockout mice.

Authors:  Cristina García-Caballero; Burke Lieppman; Alicia Arranz-Romera; Irene T Molina-Martínez; Irene Bravo-Osuna; Michael Young; Petr Baranov; Rocío Herrero-Vanrell
Journal:  Mol Vis       Date:  2018-11-16       Impact factor: 2.367

4.  Microfluidics for Advanced Drug Delivery Systems.

Authors:  Reza Riahi; Ali Tamayol; Seyed Ali Mousavi Shaegh; Amir Ghaemmaghami; Mehmet R Dokmeci; Ali Khademshosseini
Journal:  Curr Opin Chem Eng       Date:  2015-02-04       Impact factor: 5.163

5.  A Wirelessly Controlled Scalable 3D-Printed Microsystem for Drug Delivery.

Authors:  Farzad Forouzandeh; Nuzhet N Ahamed; Xiaoxia Zhu; Parveen Bazard; Krittika Goyal; Joseph P Walton; Robert D Frisina; David A Borkholder
Journal:  Pharmaceuticals (Basel)       Date:  2021-06-04

Review 6.  Recent Development of Drug Delivery Systems through Microfluidics: From Synthesis to Evaluation.

Authors:  Zhiyuan Ma; Baicheng Li; Jie Peng; Dan Gao
Journal:  Pharmaceutics       Date:  2022-02-17       Impact factor: 6.321

7.  Application of clotrimazole via a novel controlled release device provides potent retinal protection.

Authors:  Zhaleh Kashkouli Nezhad; Nobuhiro Nagai; Kotaro Yamamoto; Hirokazu Kaji; Matsuhiko Nishizawa; Hideyuki Saya; Toru Nakazawa; Toshiaki Abe
Journal:  J Mater Sci Mater Med       Date:  2015-09-03       Impact factor: 3.896
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.