| Literature DB >> 24753266 |
Kumara S Nalivela1, Michael Tilley, Michael A McGuire, Michael G Organ.
Abstract
A single pass flow diazotization/Mizoroki-Heck protocol has been developed for the production of cinnimoyl and styryl products. The factors that govern aryl diazonium salt stability have been examined in detail leading to the development of a MeOH/DMF co-solvent system in which the diazonium salts can be generated in the presence of all other reaction components and then coupled selectively to give the desired products. Finally the key role of the reaction quench for flow reactions has been demonstrated.Entities:
Keywords: Heck reaction; cross-coupling; diazonium salts; flow; microreactors
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Year: 2014 PMID： 24753266 DOI： 10.1002/chem.201402092
Source DB: PubMed Journal: Chemistry ISSN： 0947-6539 Impact factor: 5.236