Ripla Arora1, Eran Altman, Nam D Tran, Diana J Laird. 1. Department of Ob/Gyn and Reproductive Sciences, Center for Reproductive Sciences, University of California San Francisco, San Francisco, California.
Abstract
BACKGROUND: The noncanonical Wnt receptor and tyrosine kinase Ror2 has been associated with recessive Robinow syndrome (RRS) and dominant brachydactyly type B1. The phenotypes of mouse mutants implicate Ror2 in the development of the heart, lungs, bone, and craniofacial structures, which are affected in RRS. Following a recently identified role of Ror2 in the migration of mouse primordial germ cells, we extensively characterized its expression throughout the fetal internal reproductive system and the postnatal ductal system. RESULTS: We show that Ror2 gene products are present in the germ cells and somatic cells of the testis and the ovary of both the mouse and human fetus. In reproductive tract structures, we find that Ror2 is expressed in the mesonephros, developing Wolffian and Müllerian ducts, and later in their derivatives, the epididymal epithelium and uterine epithelium. CONCLUSIONS: This study sets the stage to explore function for this tyrosine kinase receptor in novel regions of expression in the developing reproductive system in both mouse and human.
BACKGROUND: The noncanonical Wnt receptor and tyrosine kinase Ror2 has been associated with recessive Robinow syndrome (RRS) and dominant brachydactyly type B1. The phenotypes of mouse mutants implicate Ror2 in the development of the heart, lungs, bone, and craniofacial structures, which are affected in RRS. Following a recently identified role of Ror2 in the migration of mouse primordial germ cells, we extensively characterized its expression throughout the fetal internal reproductive system and the postnatal ductal system. RESULTS: We show that Ror2 gene products are present in the germ cells and somatic cells of the testis and the ovary of both the mouse and human fetus. In reproductive tract structures, we find that Ror2 is expressed in the mesonephros, developing Wolffian and Müllerian ducts, and later in their derivatives, the epididymal epithelium and uterine epithelium. CONCLUSIONS: This study sets the stage to explore function for this tyrosine kinase receptor in novel regions of expression in the developing reproductive system in both mouse and human.
Authors: S Takeuchi; K Takeda; I Oishi; M Nomi; M Ikeya; K Itoh; S Tamura; T Ueda; T Hatta; H Otani; T Terashima; S Takada; H Yamamura; S Akira; Y Minami Journal: Genes Cells Date: 2000-01 Impact factor: 1.891
Authors: M Oldridge; A M Fortuna; M Maringa; P Propping; S Mansour; C Pollitt; T M DeChiara; R B Kimble; D M Valenzuela; G D Yancopoulos; A O Wilkie Journal: Nat Genet Date: 2000-03 Impact factor: 38.330
Authors: K Hatta; Z Chen; A L Carter; E Leno-Durán; J Zhang; C Ruiz-Ruiz; E G Olivares; R J MacLeod; B A Croy Journal: Placenta Date: 2010-02-10 Impact factor: 3.481
Authors: Ripla Arora; Emilie Abby; Adam D J Ross; Andrea V Cantu; Michael D Kissner; Vianca Castro; Hsin-Yi Henry Ho; Gabriel Livera; Diana J Laird Journal: J Cell Sci Date: 2016-05-19 Impact factor: 5.285