Yilin Hu1, Markus W Ribbe. 1. Department of Molecular Biology and Biochemistry, University of California, 2230 McGaugh Hall, Irvine, CA, 92697-3900, USA, yilinh@uci.edu.
Abstract
Nitrogenase catalyzes the reduction of N2 to NH3, a key step in the global nitrogen cycle. This article describes our journey toward the definition of a complete molecular structure of the active site of nitrogenase, with an emphasis on the discovery of the interstitial carbide and the radical SAM-dependent insertion of this atom into the active FeMo cofactor site of nitrogenase.
Nitrogenase catn class="Chemical">alyzes the reduction of N2 to NH3, a key step in the globalnitrogen cycle. This article describes our journey toward the definition of a complete molecular structure of the active site of nitrogenase, with an emphasis on the discovery of the interstitialcarbide and the radicalSAM-dependent insertion of this atom into the active FeMo cofactor site of nitrogenase.
Authors: Oliver Einsle; F Akif Tezcan; Susana L A Andrade; Benedikt Schmid; Mika Yoshida; James B Howard; Douglas C Rees Journal: Science Date: 2002-09-06 Impact factor: 47.728
Authors: Janice M Yoshizawa; Michael A Blank; Aaron W Fay; Chi Chung Lee; Jared A Wiig; Yilin Hu; Keith O Hodgson; Britt Hedman; Markus W Ribbe Journal: J Am Chem Soc Date: 2009-07-08 Impact factor: 15.419
Authors: Raúl Hernández Sánchez; Alexander M Willis; Shao-Liang Zheng; Theodore A Betley Journal: Angew Chem Int Ed Engl Date: 2015-08-19 Impact factor: 15.336