| Literature DB >> 24752625 |
Jian-Peng Yin1, Chun-Lan Tang, Li-Xin Gao, Wei-Ping Ma, Jing-Ya Li, Ying Li, Jia Li, Fa-Jun Nan.
Abstract
A series of structurally related analogues of the natural product paracaseolide A were synthesized and identified as potent PTP1B inhibitors. Among these analogues, compound 10 in particular showed improved PTP1B enzyme inhibitory activity, high selectivity for PTP1B over TC-PTP, and improved cellular effects.Entities:
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Year: 2014 PMID： 24752625 DOI： 10.1039/c4ob00214h
Source DB: PubMed Journal: Org Biomol Chem ISSN： 1477-0520 Impact factor: 3.876