| Literature DB >> 2475259 |
I Bank1, M Hemler, M B Brenner, D Cohen, V Levy, J Belko, C Crouse, L Chess.
Abstract
A monoclonal antibody, 1B3.1, was raised against a cloned IL-2-dependent T cell line that expresses the T gamma delta T cell receptor. MoAb 1B3.1 reacted with long-term cultured T cell lines of both T gamma delta and T alpha beta lineage, and with in vivo-stimulated T cells, derived from synovial fluid, but not with resting or short-term activated T cells, B cells, or macrophages. Immunoprecipitation of the 1B3.1 target antigens showed that 1B3.1 recognizes a 200/110 kDa molecule that is identical to the VLA-1 heterodimer precipitated by MoAb TS2/7. 1B3.1, however, binds to an epitope of VLA-1 that is distinct from the TS2/7 binding site. This new MoAb could be useful in further studies of the functions of VLA-1, and of the cells that express this molecule.Entities:
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Year: 1989 PMID： 2475259 DOI： 10.1016/0008-8749(89)90088-9
Source DB: PubMed Journal: Cell Immunol ISSN： 0008-8749 Impact factor: 4.868