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Literature DB >> 24752304

oxLDL-induced lipid accumulation in glomerular podocytes: role of IFN-γ, CXCL16, and ADAM10.

Li Wang¹, Shuzhen Sun, Aihua Zhou, Xiujun Yao, Yulin Wang.

Abstract

Previous studies have shown that lipid accumulation plays an important role in the pathogenesis and development of glomerular sclerosis. oxLDL caused damage in renal mesangial cells, endothelial cells, and podocytes, and podocytes might be the major victim of oxLDL insult. However, the regulatory mechanism of how oxLDL induces the damage of podocytes remains to be elucidated. In this study, oil red staining was used to investigate the lipid accumulation in podocytes. Moreover, the effects of CXCL16 antibody, IFN-γ, and ADAM10 inhibitor on oxLDL intake and CXCL16 expression were also explored to elucidate the regulatory factors of lipid accumulation in podocytes.

Entities: Chemical Disease Gene

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Year: 2014 PMID： 24752304 DOI： 10.1007/s12013-014-9952-1

Source DB: PubMed Journal: Cell Biochem Biophys ISSN： 1085-9195 Impact factor: 2.194

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Cited

6 in total

1. Simvastatin ameliorates renal lipidosis through the suppression of renal CXCL16 expression in mice with adriamycin-induced nephropathy.

Authors: Cong Wang; Qian Li; Junhui Zhen; Yihuai Xu; Shuzhen Sun
Journal: Int J Clin Exp Pathol Date: 2015-12-01

2. Platelet-Derived Exosomal MicroRNA-25-3p Inhibits Coronary Vascular Endothelial Cell Inflammation Through Adam10 via the NF-κB Signaling Pathway in ApoE^-/- Mice.

Authors: Ye Yao; Weidong Sun; Qingfeng Sun; Bao Jing; Siqi Liu; Xinyu Liu; Guanghui Shen; Ru Chen; Haiyang Wang
Journal: Front Immunol Date: 2019-10-02 Impact factor: 7.561

6. Atorvastatin Decreases Renal Calcium Oxalate Stone Deposits by Enhancing Renal Osteopontin Expression in Hyperoxaluric Stone-Forming Rats Fed a High-Fat Diet.

Authors: Chan Jung Liu; Yau Sheng Tsai; Ho Shiang Huang
Journal: Int J Mol Sci Date: 2022-03-11 Impact factor: 5.923

6 in total

oxLDL-induced lipid accumulation in glomerular podocytes: role of IFN-γ, CXCL16, and ADAM10.

1. Simvastatin ameliorates renal lipidosis through the suppression of renal CXCL16 expression in mice with adriamycin-induced nephropathy.

2. Platelet-Derived Exosomal MicroRNA-25-3p Inhibits Coronary Vascular Endothelial Cell Inflammation Through Adam10 via the NF-κB Signaling Pathway in ApoE^-/- Mice.

Review 3. Role of Podocyte Injury in Glomerulosclerosis.

4. oxLDL promotes podocyte migration by regulating CXCL16, ADAM10 and ACTN4.

5. CXCL16/ERK1/2 pathway regulates human podocytes growth, migration, apoptosis and epithelial mesenchymal transition.

6. Atorvastatin Decreases Renal Calcium Oxalate Stone Deposits by Enhancing Renal Osteopontin Expression in Hyperoxaluric Stone-Forming Rats Fed a High-Fat Diet.

oxLDL-induced lipid accumulation in glomerular podocytes: role of IFN-γ, CXCL16, and ADAM10.

1. Simvastatin ameliorates renal lipidosis through the suppression of renal CXCL16 expression in mice with adriamycin-induced nephropathy.

2. Platelet-Derived Exosomal MicroRNA-25-3p Inhibits Coronary Vascular Endothelial Cell Inflammation Through Adam10 via the NF-κB Signaling Pathway in ApoE-/- Mice.

Review 3. Role of Podocyte Injury in Glomerulosclerosis.

4. oxLDL promotes podocyte migration by regulating CXCL16, ADAM10 and ACTN4.

5. CXCL16/ERK1/2 pathway regulates human podocytes growth, migration, apoptosis and epithelial mesenchymal transition.

6. Atorvastatin Decreases Renal Calcium Oxalate Stone Deposits by Enhancing Renal Osteopontin Expression in Hyperoxaluric Stone-Forming Rats Fed a High-Fat Diet.

2. Platelet-Derived Exosomal MicroRNA-25-3p Inhibits Coronary Vascular Endothelial Cell Inflammation Through Adam10 via the NF-κB Signaling Pathway in ApoE^-/- Mice.