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Literature DB >> 24751824

Studying aging in Drosophila.

Abstract

Drosophila melanogaster represents one of the most important genetically accessible model organisms for aging research. Studies in flies have identified single gene mutations that influence lifespan and have characterized endocrine signaling interactions that control homeostasis systemically. Recent studies have focused on the effects of aging on specific tissues and physiological processes, providing a comprehensive picture of age-related tissue dysfunction and the loss of systemic homeostasis. Here we review methodological aspects of this work and highlight technical considerations when using Drosophila to study aging and age-related diseases.

Entities: Chemical Disease Gene Species

Keywords: Aging; Degeneration; Drosophila; Homeostasis

Mesh：

Year: 2014 PMID： 24751824 PMCID： PMC4066732 DOI： 10.1016/j.ymeth.2014.04.008

Source DB: PubMed Journal: Methods ISSN： 1046-2023 Impact factor: 3.608

106 in total

1. A conditional tissue-specific transgene expression system using inducible GAL4.

Authors: T Osterwalder; K S Yoon; B H White; H Keshishian
Journal: Proc Natl Acad Sci U S A Date: 2001-10-23 Impact factor: 11.205

2. A model for studying Alzheimer's Abeta42-induced toxicity in Drosophila melanogaster.

Authors: Alyce Finelli; Anju Kelkar; Ho-Juhn Song; Haidi Yang; Mary Konsolaki
Journal: Mol Cell Neurosci Date: 2004-07 Impact factor: 4.314

Review 3. Cardiac aging.

Authors: Robert J Wessells; Rolf Bodmer
Journal: Semin Cell Dev Biol Date: 2006-12-27 Impact factor: 7.727

4. Dynamic coordination of innate immune signaling and insulin signaling regulates systemic responses to localized DNA damage.

Authors: Jason Karpac; Andrew Younger; Heinrich Jasper
Journal: Dev Cell Date: 2011-06-14 Impact factor: 12.270

Review 5. Regulation of Drosophila lifespan by JNK signaling.

Authors: Benoit Biteau; Jason Karpac; Daesung Hwangbo; Heinrich Jasper
Journal: Exp Gerontol Date: 2010-11-25 Impact factor: 4.032

6. FOXO/4E-BP signaling in Drosophila muscles regulates organism-wide proteostasis during aging.

Authors: Fabio Demontis; Norbert Perrimon
Journal: Cell Date: 2010-11-24 Impact factor: 41.582

Review 7. Functional senescence in Drosophila melanogaster.

Authors: Michael S Grotewiel; Ian Martin; Poonam Bhandari; Eric Cook-Wiens
Journal: Ageing Res Rev Date: 2005-08 Impact factor: 10.895

8. Sleep, aging, and lifespan in Drosophila.

Authors: Daniel Bushey; Kimberly A Hughes; Giulio Tononi; Chiara Cirelli
Journal: BMC Neurosci Date: 2010-04-29 Impact factor: 3.288

9. Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway.

Authors: Pankaj Kapahi; Brian M Zid; Tony Harper; Daniel Koslover; Viveca Sapin; Seymour Benzer
Journal: Curr Biol Date: 2004-05-25 Impact factor: 10.834

10. No influence of Indy on lifespan in Drosophila after correction for genetic and cytoplasmic background effects.

Authors: Janne M Toivonen; Glenda A Walker; Pedro Martinez-Diaz; Ivana Bjedov; Yasmine Driege; Howard T Jacobs; David Gems; Linda Partridge
Journal: PLoS Genet Date: 2007-04-30 Impact factor: 5.917

41 in total

1. Translational Geroscience: From invertebrate models to companion animal and human interventions.

Authors: Mitchell B Lee; Matt Kaeberlein
Journal: Transl Med Aging Date: 2018-08-17

2. Aging and circadian dysfunction increase alcohol sensitivity and exacerbate mortality in Drosophila melanogaster.

Authors: Aliza K De Nobrega; Alana P Mellers; Lisa C Lyons
Journal: Exp Gerontol Date: 2017-07-25 Impact factor: 4.032

3. Cytokine signaling through Drosophila Mthl10 ties lifespan to environmental stress.

Authors: Eui Jae Sung; Masasuke Ryuda; Hitoshi Matsumoto; Outa Uryu; Masanori Ochiai; Molly E Cook; Na Young Yi; Huanchen Wang; James W Putney; Gary S Bird; Stephen B Shears; Yoichi Hayakawa
Journal: Proc Natl Acad Sci U S A Date: 2017-12-11 Impact factor: 11.205

4. Deficits in the vesicular acetylcholine transporter alter lifespan and behavior in adult Drosophila melanogaster.

Authors: Daniel White; Raquel P de Sousa Abreu; Andrew Blake; Jeremy Murphy; Shardae Showell; Toshihiro Kitamoto; Hakeem O Lawal
Journal: Neurochem Int Date: 2020-04-18 Impact factor: 3.921

5. Pterostilbene Promotes Mean Lifespan in Both Male and Female Drosophila Melanogaster Modulating Different Proteins in the Two Sexes.

Authors: Daniela Beghelli; Lorenzo Zallocco; Maria Cristina Barbalace; Simona Paglia; Silvia Strocchi; Ilenia Cirilli; Valeria Marzano; Lorenza Putignani; Giulio Lupidi; Silvana Hrelia; Laura Giusti; Cristina Angeloni
Journal: Oxid Med Cell Longev Date: 2022-02-16 Impact factor: 6.543

6. Wear and tear of the intestinal visceral musculature by intrinsic and extrinsic factors.

Authors: Ho D Kim; Eric So; Jiae Lee; Yi Wang; Vikram S Gill; Anna Gorbacheva; Hee Jin Han; Katelyn G-L Ng; Ken Ning; Inez K A Pranoto; Alejandra J H Cabrera; Dae Seok Eom; Young V Kwon
Journal: Dev Dyn Date: 2022-04-07 Impact factor: 2.842

7. Alterations in biogenic amines levels associated with age-related muscular tissue impairment in Drosophila melanogaster.

Authors: Iman M El Husseiny; Samar El Kholy; Amira Z Mohamed; Wesam S Meshrif; Hanaa Elbrense
Journal: Saudi J Biol Sci Date: 2022-03-11 Impact factor: 4.052