Matthew I Tomey1, Jonathan A Winston2. 1. Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY. Electronic address: matthew.tomey@mountsinai.org. 2. Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY.
Abstract
BACKGROUND: Chronic kidney disease (CKD) is common, and is associated with a high burden of cardiovascular disease. This cardiovascular risk is incompletely explained by traditional risk factors, calling attention to a need to better understand the pathways in CKD contributing to adverse cardiovascular outcomes. FINDINGS: Pathophysiological derangements associated with CKD, including disordered sodium, potassium, and water homeostasis, renin-angiotensin-aldosterone and sympathetic activity, anemia, bone and mineral metabolism, uremia, and toxin accumulation may contribute directly to progression of cardiovascular disease and adverse outcomes. CONCLUSION: Improving cardiovascular health in patients with CKD requires improved understanding of renocardiac pathophysiology. Ultimately, the most successful strategy may be prevention of incident CKD itself.
BACKGROUND:Chronic kidney disease (CKD) is common, and is associated with a high burden of cardiovascular disease. This cardiovascular risk is incompletely explained by traditional risk factors, calling attention to a need to better understand the pathways in CKD contributing to adverse cardiovascular outcomes. FINDINGS: Pathophysiological derangements associated with CKD, including disordered sodium, potassium, and water homeostasis, renin-angiotensin-aldosterone and sympathetic activity, anemia, bone and mineral metabolism, uremia, and toxin accumulation may contribute directly to progression of cardiovascular disease and adverse outcomes. CONCLUSION: Improving cardiovascular health in patients with CKD requires improved understanding of renocardiac pathophysiology. Ultimately, the most successful strategy may be prevention of incident CKD itself.
Authors: Jonah M Graves; Julian A Vallejo; Chelsea S Hamill; Derek Wang; Rohan Ahuja; Shaan Patel; Christian Faul; Michael J Wacker Journal: Am J Physiol Heart Circ Physiol Date: 2021-04-30 Impact factor: 5.125
Authors: Julie H Ishida; Cynthia Chauhan; Barbara Gillespie; Ken Gruchalla; Peter A McCullough; Susan Quella; Alain Romero; Patrick Rossignol; David C Wheeler; Meaghan A Malley; Melissa West; Charles A Herzog Journal: Clin J Am Soc Nephrol Date: 2021-04-23 Impact factor: 10.614