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Literature DB >> 24751356

Zinc transporter 8 (ZnT8) and β cell function.

Howard W Davidson¹, Janet M Wenzlau², Richard M O'Brien³.

Abstract

Human pancreatic β cells have exceptionally high zinc content. In β cells the highest zinc concentration is in insulin secretory granules, from which it is cosecreted with the hormone. Uptake of zinc into secretory granules is mainly mediated by zinc transporter 8 (ZnT8), the product of the SLC30A8 [solute carrier family 30 (zinc transporter), member 8] gene. The minor alleles of several single-nucleotide polymorphisms (SNPs) in SLC30A8 are associated with decreased risk of type 2 diabetes (T2D), but the precise mechanisms underlying the protective effects remain uncertain. In this article we review current knowledge of the role of ZnT8 in maintaining zinc homeostasis in β cells, its role in glucose metabolism based on knockout mouse studies, and current theories regarding the link between ZnT8 function and T2D.

Entities: CellLine Chemical Disease Gene Mutation Species

Keywords: SLC30A8; Slc30a8; islet

Mesh：

Substances：

Year: 2014 PMID： 24751356 PMCID： PMC4112161 DOI： 10.1016/j.tem.2014.03.008

Source DB: PubMed Journal: Trends Endocrinol Metab ISSN： 1043-2760 Impact factor: 12.015

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Authors: Samer Salamekh; Jeffrey R Brender; Suk-Joon Hyung; Ravi Prakash Reddy Nanga; Subramanian Vivekanandan; Brandon T Ruotolo; Ayyalusamy Ramamoorthy
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Review 2. Islet amyloid polypeptide, islet amyloid, and diabetes mellitus.

Authors: Per Westermark; Arne Andersson; Gunilla T Westermark
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3. Effects of high-fat diet feeding on Znt8-null mice: differences between β-cell and global knockout of Znt8.

Authors: A B Hardy; N Wijesekara; I Genkin; K J Prentice; A Bhattacharjee; D Kong; F Chimienti; M B Wheeler
Journal: Am J Physiol Endocrinol Metab Date: 2012-02-14 Impact factor: 4.310

4. Three-dimensional structure of beta-cell-specific zinc transporter, ZnT-8, predicted from the type 2 diabetes-associated gene variant SLC30A8 R325W.

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Journal: Diabetol Metab Syndr Date: 2010-06-05 Impact factor: 3.320

5. Diabetes-linked zinc transporter ZnT8 is a homodimeric protein expressed by distinct rodent endocrine cell types in the pancreas and other glands.

Authors: C Murgia; C Devirgiliis; E Mancini; G Donadel; P Zalewski; G Perozzi
Journal: Nutr Metab Cardiovasc Dis Date: 2008-12-17 Impact factor: 4.222

6. Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.

Authors: Richa Saxena; Benjamin F Voight; Valeriya Lyssenko; Noël P Burtt; Paul I W de Bakker; Hong Chen; Jeffrey J Roix; Sekar Kathiresan; Joel N Hirschhorn; Mark J Daly; Thomas E Hughes; Leif Groop; David Altshuler; Peter Almgren; Jose C Florez; Joanne Meyer; Kristin Ardlie; Kristina Bengtsson Boström; Bo Isomaa; Guillaume Lettre; Ulf Lindblad; Helen N Lyon; Olle Melander; Christopher Newton-Cheh; Peter Nilsson; Marju Orho-Melander; Lennart Råstam; Elizabeth K Speliotes; Marja-Riitta Taskinen; Tiinamaija Tuomi; Candace Guiducci; Anna Berglund; Joyce Carlson; Lauren Gianniny; Rachel Hackett; Liselotte Hall; Johan Holmkvist; Esa Laurila; Marketa Sjögren; Maria Sterner; Aarti Surti; Margareta Svensson; Malin Svensson; Ryan Tewhey; Brendan Blumenstiel; Melissa Parkin; Matthew Defelice; Rachel Barry; Wendy Brodeur; Jody Camarata; Nancy Chia; Mary Fava; John Gibbons; Bob Handsaker; Claire Healy; Kieu Nguyen; Casey Gates; Carrie Sougnez; Diane Gage; Marcia Nizzari; Stacey B Gabriel; Gung-Wei Chirn; Qicheng Ma; Hemang Parikh; Delwood Richardson; Darrell Ricke; Shaun Purcell
Journal: Science Date: 2007-04-26 Impact factor: 47.728

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Authors: Liping Huang; Catherine P Kirschke; Yu-An E Lay; Lauren B Levy; Danielle E Lamirande; Patrick H Zhang
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Journal: Invest Ophthalmol Vis Sci Date: 2008-03 Impact factor: 4.799

9. Total zinc intake may modify the glucose-raising effect of a zinc transporter (SLC30A8) variant: a 14-cohort meta-analysis.

Authors: Stavroula Kanoni; Jennifer A Nettleton; Marie-France Hivert; Zheng Ye; Frank J A van Rooij; Dmitry Shungin; Emily Sonestedt; Julius S Ngwa; Mary K Wojczynski; Rozenn N Lemaitre; Stefan Gustafsson; Jennifer S Anderson; Toshiko Tanaka; George Hindy; Georgia Saylor; Frida Renstrom; Amanda J Bennett; Cornelia M van Duijn; Jose C Florez; Caroline S Fox; Albert Hofman; Ron C Hoogeveen; Denise K Houston; Frank B Hu; Paul F Jacques; Ingegerd Johansson; Lars Lind; Yongmei Liu; Nicola McKeown; Jose Ordovas; James S Pankow; Eric J G Sijbrands; Ann-Christine Syvänen; André G Uitterlinden; Mary Yannakoulia; M Carola Zillikens; Nick J Wareham; Inga Prokopenko; Stefania Bandinelli; Nita G Forouhi; L Adrienne Cupples; Ruth J Loos; Goran Hallmans; Josée Dupuis; Claudia Langenberg; Luigi Ferrucci; Stephen B Kritchevsky; Mark I McCarthy; Erik Ingelsson; Ingrid B Borecki; Jacqueline C M Witteman; Marju Orho-Melander; David S Siscovick; James B Meigs; Paul W Franks; George V Dedoussis
Journal: Diabetes Date: 2011-08-01 Impact factor: 9.461

10. The genetic susceptibility to type 2 diabetes may be modulated by obesity status: implications for association studies.

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2. The Diabetes Susceptibility Gene SLC30A8 that Encodes the Zinc Transporter ZnT8 is a Pseudogene in Guinea Pigs Potentially Contributing to Low Guinea Pig Islet Zinc Content.

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4. Zinc.

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5. ZIGIR, a Granule-Specific Zn²⁺ Indicator, Reveals Human Islet α Cell Heterogeneity.

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Review 6. The Pancreatic β-Cell: The Perfect Redox System.

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7. Zinc Transport Gets Its Zing Back: Double-Knockout of ZnT7 and ZnT8 Reveals the Importance of Zinc Transporters to Insulin Secretion.

Authors: Craig S Nunemaker; Richard K P Benninger
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