| Literature DB >> 24751235 |
Kazuyo Kikuchi1, Akira Watanabe2, Junko Ito1, Yukio Oku1, Tuya Wuren1, Hideaki Taguchi1, Kyoko Yarita1, Yasunori Muraosa1, Maki Yahiro1, Takashi Yaguchi1, Katsuhiko Kamei3.
Abstract
Azole resistance among clinical isolates of Aspergillus fumigatus is becoming a serious problem in Europe, but the status in Japan is not yet known in detail. The aim of this study was to determine the present status of azole resistance in A. fumigatus in Japan. We employed 171 clinical isolates of A. fumigatus sensu stricto collected from 1987 to 2008 at the Medical Mycology Research Center, Chiba University, Japan for azole resistance determination. Identification of all isolates were re-examined both from the aspect of morphology and molecular phylogeny. The antifungal susceptibility of these isolates was tested based on the CLSI M38-A2 broth microdilution method. In our collection, only 1 (0.6%) and 2 isolates (1.2%) showed elevated MIC to voriconazole and itraconazole, respectively. Our study disclosed that the frequency of azole resistance in A. fumigatus still remains low in this collection.Entities:
Keywords: Azole resistance; Beta-tubulin gene; Itraconazole; Voriconazole
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Year: 2014 PMID： 24751235 DOI： 10.1016/j.jiac.2014.01.003
Source DB: PubMed Journal: J Infect Chemother ISSN： 1341-321X Impact factor: 2.211