OBJECTIVES: There are no prospective studies of laparoscopic microwave (MW) ablation in patients with hepatocellular carcinoma (HCC). The aim of this study was to demonstrate the safety and efficacy of laparoscopic MW ablation. METHODS: A prospective study group of consecutive HCC patients considered ineligible for liver resection and/or percutaneous ablation was conducted from December 2009 to December 2010. Short-term (3-month) outcomes included a centralized revision of radiological response, mortality and morbidity. Mid-term (24-month) outcomes included time to recurrence in the study group compared with that in a cohort of consecutive patients treated with laparoscopic radiofrequency (RF) ablation using propensity score analysis. RESULTS: A total of 42 patients were enrolled. Their median age was 64 years; 67% were positive for hepatitis C virus; 33% were of Child-Pugh class B status; the median tumour diameter was 2.5 cm, and 48% of patients had multinodular HCC. In 47 of 50 (94%) nodules treated with MW ablation, a complete radiological response was observed at 3 months. There was no perioperative mortality. The overall morbidity rate was 24%. The 2-year survival rate was 79% and the 2-year recurrence rate was 55%. Using propensity score analysis (in 28 MW ablation patients and 28 RF ablation controls), 2-year recurrence rates were 55% in the MW ablation group and 77% in the control group (P = 0.03). CONCLUSIONS: Laparoscopic MW ablation is a safe and effective therapeutic option for selected HCC patients who are ineligible for liver resection and/or percutaneous ablation.
OBJECTIVES: There are no prospective studies of laparoscopic microwave (MW) ablation in patients with hepatocellular carcinoma (HCC). The aim of this study was to demonstrate the safety and efficacy of laparoscopic MW ablation. METHODS: A prospective study group of consecutive HCC patients considered ineligible for liver resection and/or percutaneous ablation was conducted from December 2009 to December 2010. Short-term (3-month) outcomes included a centralized revision of radiological response, mortality and morbidity. Mid-term (24-month) outcomes included time to recurrence in the study group compared with that in a cohort of consecutive patients treated with laparoscopic radiofrequency (RF) ablation using propensity score analysis. RESULTS: A total of 42 patients were enrolled. Their median age was 64 years; 67% were positive for hepatitis C virus; 33% were of Child-Pugh class B status; the median tumour diameter was 2.5 cm, and 48% of patients had multinodular HCC. In 47 of 50 (94%) nodules treated with MW ablation, a complete radiological response was observed at 3 months. There was no perioperative mortality. The overall morbidity rate was 24%. The 2-year survival rate was 79% and the 2-year recurrence rate was 55%. Using propensity score analysis (in 28 MW ablation patients and 28 RF ablation controls), 2-year recurrence rates were 55% in the MW ablation group and 77% in the control group (P = 0.03). CONCLUSIONS: Laparoscopic MW ablation is a safe and effective therapeutic option for selected HCC patients who are ineligible for liver resection and/or percutaneous ablation.
Authors: J-L Raoul; B Sangro; A Forner; V Mazzaferro; F Piscaglia; L Bolondi; R Lencioni Journal: Cancer Treat Rev Date: 2010-08-17 Impact factor: 12.111
Authors: Maurizio Pompili; Antonio Saviano; Nicoletta de Matthaeis; Alessandro Cucchetti; Francesco Ardito; Bruno Federico; Franco Brunello; Antonio D Pinna; Antonio Giorgio; Stefano M Giulini; Ilario De Sio; Guido Torzilli; Fabio Fornari; Lorenzo Capussotti; Alfredo Guglielmi; Fabio Piscaglia; Luca Aldrighetti; Eugenio Caturelli; Fulvio Calise; Gennaro Nuzzo; Gian Ludovico Rapaccini; Felice Giuliante Journal: J Hepatol Date: 2013-03-22 Impact factor: 25.083
Authors: Erin H Baker; Kyle Thompson; Iain H McKillop; Allyson Cochran; Russell Kirks; Dionisios Vrochides; John B Martinie; Ryan Z Swan; David A Iannitti Journal: J Gastrointest Oncol Date: 2017-04
Authors: Mrudula B Glassberg; Sudip Ghosh; Jeffrey W Clymer; Rana A Qadeer; Nicole C Ferko; Behnam Sadeghirad; George Wj Wright; Joseph F Amaral Journal: Onco Targets Ther Date: 2019-08-13 Impact factor: 4.147