Literature DB >> 24750028

One-pot synthesis of ureas from Boc-protected amines.

Constantinos Spyropoulos1, Christoforos G Kokotos.   

Abstract

A practical one-pot synthesis of ureas is described. Boc-protected amines can be transformed into nonsymmetrical and symmetrical disubstituted and trisubstituted ureas utilizing 2-chloropyridine and trifluoromethanesulfonyl anhydride for the in situ generation of an isocyanate, which reacts with an amine. A variety of amines can be employed successfully, leading to high yields of isolated ureas.

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Year:  2014        PMID： 24750028     DOI： 10.1021/jo500492x

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  4 in total

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Journal:  J Med Chem       Date:  2019-12-02       Impact factor: 7.446

2.  Efficient access to 3'-O-phosphoramidite derivatives of tRNA related N 6-threonylcarbamoyladenosine (t6A) and 2-methylthio-N 6-threonylcarbamoyladenosine (ms2t6A).

Authors:  Katarzyna Debiec; Elzbieta Sochacka
Journal:  RSC Adv       Date:  2021-01-07       Impact factor: 3.361

3.  Practical one-pot amidation of N-Alloc-, N-Boc-, and N-Cbz protected amines under mild conditions.

Authors:  Wan Pyo Hong; Van Hieu Tran; Hee-Kwon Kim
Journal:  RSC Adv       Date:  2021-04-28       Impact factor: 3.361

4.  Simple and efficient synthesis of bicyclic enol-carbamates: access to brabantamides and their analogues.

Authors:  Ondrej Záborský; Ľudmila Petrovičová; Jana Doháňošová; Ján Moncol; Róbert Fischer
Journal:  RSC Adv       Date:  2020-02-13       Impact factor: 4.036
  4 in total

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