Literature DB >> 24749631

Whole exome sequencing to estimate alloreactivity potential between donors and recipients in stem cell transplantation.

Juliana K Sampson1, Nihar U Sheth, Vishal N Koparde, Allison F Scalora, Myrna G Serrano, Vladimir Lee, Catherine H Roberts, Max Jameson-Lee, Andrea Ferreira-Gonzalez, Masoud H Manjili, Gregory A Buck, Michael C Neale, Amir A Toor.   

Abstract

Whole exome sequencing (WES) was performed on stem cell transplant donor-recipient (D-R) pairs to determine the extent of potential antigenic variation at a molecular level. In a small cohort of D-R pairs, a high frequency of sequence variation was observed between the donor and recipient exomes independent of human leucocyte antigen (HLA) matching. Nonsynonymous, nonconservative single nucleotide polymorphisms were approximately twice as frequent in HLA-matched unrelated, compared with related D-R pairs. When mapped to individual chromosomes, these polymorphic nucleotides were uniformly distributed across the entire exome. In conclusion, WES reveals extensive nucleotide sequence variation in the exomes of HLA-matched donors and recipients.
© 2014 John Wiley & Sons Ltd.

Entities:  

Keywords:  alloreactivity potential; graft-versus-host disease; single nucleotide polymorphism; stem cell transplant; whole exome sequencing

Mesh：

Year:  2014        PMID： 24749631      PMCID： PMC4964978          DOI： 10.1111/bjh.12898

Source DB:  PubMed          Journal:  Br J Haematol        ISSN： 0007-1048            Impact factor:   6.998


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1.  Dynamical System Modeling of Immune Reconstitution after Allogeneic Stem Cell Transplantation Identifies Patients at Risk for Adverse Outcomes.

Authors:  Amir A Toor; Roy T Sabo; Catherine H Roberts; Bonny L Moore; Salman R Salman; Allison F Scalora; May T Aziz; Ali S Shubar Ali; Charles E Hall; Jeremy Meier; Radhika M Thorn; Elaine Wang; Shiyu Song; Kristin Miller; Kathryn Rizzo; William B Clark; John M McCarty; Harold M Chung; Masoud H Manjili; Michael C Neale
Journal:  Biol Blood Marrow Transplant       Date:  2015-04-04       Impact factor: 5.742

Review 2.  Transplant genetics and genomics.

Authors:  Joshua Y C Yang; Minnie M Sarwal
Journal:  Nat Rev Genet       Date:  2017-03-13       Impact factor: 53.242

3.  Chromosome Y-encoded antigens associate with acute graft-versus-host disease in sex-mismatched stem cell transplant.

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Journal:  Blood Adv       Date:  2018-10-09

4.  Dynamical System Modeling to Simulate Donor T Cell Response to Whole Exome Sequencing-Derived Recipient Peptides Demonstrates Different Alloreactivity Potential in HLA-Matched and -Mismatched Donor-Recipient Pairs.

Authors:  Badar Abdul Razzaq; Allison Scalora; Vishal N Koparde; Jeremy Meier; Musa Mahmood; Salman Salman; Max Jameson-Lee; Myrna G Serrano; Nihar Sheth; Mark Voelkner; David J Kobulnicky; Catherine H Roberts; Andrea Ferreira-Gonzalez; Masoud H Manjili; Gregory A Buck; Michael C Neale; Amir A Toor
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5.  Dynamical Systems Modeling of Early-Term Immune Reconstitution with Different Antithymocyte Globulin Administration Schedules in Allogeneic Stem Cell Transplantation.

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Review 6.  Minor histocompatibility Ags: identification strategies, clinical results and translational perspectives.

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Journal:  Bone Marrow Transplant       Date:  2015-10-26       Impact factor: 5.483

7.  Recurrent genetic HLA loss in AML relapsed after matched unrelated allogeneic hematopoietic cell transplantation.

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Review 8.  In silico Derivation of HLA-Specific Alloreactivity Potential from Whole Exome Sequencing of Stem-Cell Transplant Donors and Recipients: Understanding the Quantitative Immunobiology of Allogeneic Transplantation.

Authors:  Max Jameson-Lee; Vishal Koparde; Phil Griffith; Allison F Scalora; Juliana K Sampson; Haniya Khalid; Nihar U Sheth; Michael Batalo; Myrna G Serrano; Catherine H Roberts; Michael L Hess; Gregory A Buck; Michael C Neale; Masoud H Manjili; Amir Ahmed Toor
Journal:  Front Immunol       Date:  2014-11-06       Impact factor: 7.561

Review 9.  Stem cell transplantation as a dynamical system: are clinical outcomes deterministic?

Authors:  Amir A Toor; Jared D Kobulnicky; Salman Salman; Catherine H Roberts; Max Jameson-Lee; Jeremy Meier; Allison Scalora; Nihar Sheth; Vishal Koparde; Myrna Serrano; Gregory A Buck; William B Clark; John M McCarty; Harold M Chung; Masoud H Manjili; Roy T Sabo; Michael C Neale
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10.  Dynamical system modeling to simulate donor T cell response to whole exome sequencing-derived recipient peptides: Understanding randomness in alloreactivity incidence following stem cell transplantation.

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