| Literature DB >> 24747560 |
Katie L Lannan1, Richard P Phipps2, R James White3.
Abstract
Pulmonary arterial hypertension (PAH) is a progressive disease that involves pathological remodeling, vasoconstriction and thrombosis. Alterations in hemostasis, coagulation and platelet activation are consistently observed in PAH patients. Microparticles derived from platelets, inflammatory cells and the endothelium are an increasingly well-recognized signal in a variety of cardiovascular diseases, including PAH. This review will focus on the roles of coagulation, thrombosis, platelet activation and microparticles in the pathology and progression of PAH.Entities:
Mesh:
Year: 2014 PMID: 24747560 PMCID: PMC4386061 DOI: 10.1016/j.drudis.2014.04.001
Source DB: PubMed Journal: Drug Discov Today ISSN: 1359-6446 Impact factor: 7.851