Literature DB >> 24747527

Antimicrobial mechanisms: a sponge against fungal infections.

Karl Lohner1.   

Abstract

The finding that the antifungal activity of amphotericin B is primarily due to its ability to extract ergosterol from fungal membranes suggests a new rationale for drug design, which should lead to advanced treatments, particularly for invasive fungal infections.

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Year:  2014        PMID： 24747527     DOI： 10.1038/nchembio.1518

Source DB:  PubMed          Journal:  Nat Chem Biol        ISSN： 1552-4450            Impact factor:   15.040


  9 in total

1.  Amphotericin primarily kills yeast by simply binding ergosterol.

Authors:  Kaitlyn C Gray; Daniel S Palacios; Ian Dailey; Matthew M Endo; Brice E Uno; Brandon C Wilcock; Martin D Burke
Journal:  Proc Natl Acad Sci U S A       Date:  2012-01-17       Impact factor: 11.205

2.  Tackling human fungal infections.

Authors:  Gordon D Brown; David W Denning; Stuart M Levitz
Journal:  Science       Date:  2012-05-11       Impact factor: 47.728

3.  Binding of antibiotic amphotericin B to lipid membranes: monomolecular layer technique and linear dichroism-FTIR studies.

Authors:  Mariusz Gagoś; Janina Gabrielska; Mauro Dalla Serra; Wiesław I Gruszecki
Journal:  Mol Membr Biol       Date:  2005 Sep-Oct       Impact factor: 2.857

Review 4.  Antifungal drug resistance: mechanisms, epidemiology, and consequences for treatment.

Authors:  Michael A Pfaller
Journal:  Am J Med       Date:  2012-01       Impact factor: 4.965

5.  Visualization analysis of the vacuole-targeting fungicidal activity of amphotericin B against the parent strain and an ergosterol-less mutant of Saccharomyces cerevisiae.

Authors:  Chang-Kyung Kang; Keiichi Yamada; Yoshinosuke Usuki; Akira Ogita; Ken-Ichi Fujita; Toshio Tanaka
Journal:  Microbiology       Date:  2013-03-08       Impact factor: 2.777

Review 6.  Cryptococcal meningitis: improving access to essential antifungal medicines in resource-poor countries.

Authors:  Angela Loyse; Harry Thangaraj; Philippa Easterbrook; Nathan Ford; Monika Roy; Tom Chiller; Nelesh Govender; Thomas S Harrison; Tihana Bicanic
Journal:  Lancet Infect Dis       Date:  2013-06-02       Impact factor: 25.071

7.  It only takes one to do many jobs: Amphotericin B as antifungal and immunomodulatory drug.

Authors:  Ana C Mesa-Arango; Liliana Scorzoni; Oscar Zaragoza
Journal:  Front Microbiol       Date:  2012-08-08       Impact factor: 5.640

8.  Amphotericin forms an extramembranous and fungicidal sterol sponge.

Authors:  Thomas M Anderson; Mary C Clay; Alexander G Cioffi; Katrina A Diaz; Grant S Hisao; Marcus D Tuttle; Andrew J Nieuwkoop; Gemma Comellas; Nashrah Maryum; Shu Wang; Brice E Uno; Erin L Wildeman; Tamir Gonen; Chad M Rienstra; Martin D Burke
Journal:  Nat Chem Biol       Date:  2014-03-30       Impact factor: 15.040

9.  Neutron diffraction studies of the interaction between amphotericin B and lipid-sterol model membranes.

Authors:  Fabrizia Foglia; M Jayne Lawrence; Bruno Demeė; Giovanna Fragneto; David Barlow
Journal:  Sci Rep       Date:  2012-10-29       Impact factor: 4.379
  9 in total
  6 in total

1.  Supramolecular Chitosan Micro-Platelets Synergistically Enhance Anti-Candida albicans Activity of Amphotericin B Using an Immunocompetent Murine Model.

Authors:  Tiphany Grisin; Christian Bories; Martina Bombardi; Philippe M Loiseau; Valérie Rouffiac; Audrey Solgadi; Jean-Maurice Mallet; Gilles Ponchel; Kawthar Bouchemal
Journal:  Pharm Res       Date:  2017-02-06       Impact factor: 4.200

Review 2.  Role of Lipid Composition, Physicochemical Interactions, and Membrane Mechanics in the Molecular Actions of Microbial Cyclic Lipopeptides.

Authors:  Daniel Balleza; Andrea Alessandrini; Miguel J Beltrán García
Journal:  J Membr Biol       Date:  2019-05-16       Impact factor: 1.843

3.  Current and promising pharmacotherapeutic options for candidiasis.

Authors:  Liliana Scorzoni; Beth Burgwyn Fuchs; Juliana Campos Junqueira; Eleftherios Mylonakis
Journal:  Expert Opin Pharmacother       Date:  2021-02-04       Impact factor: 3.889

4.  Combination treatment of ergosterol followed by amphotericin B induces necrotic cell death in human hepatocellular carcinoma cells.

Authors:  Yu-Chun Lin; Bao-Hong Lee; Jassey Alagie; Ching-Hua Su
Journal:  Oncotarget       Date:  2017-08-16

5.  Low-dose polymyxin: an option for therapy of Gram-negative sepsis.

Authors:  Stephan Harm; Franz Gabor; Jens Hartmann
Journal:  Innate Immun       Date:  2016-03-17       Impact factor: 2.680

Review 6.  Antimicrobial Peptides Targeting Gram-Positive Bacteria.

Authors:  Nermina Malanovic; Karl Lohner
Journal:  Pharmaceuticals (Basel)       Date:  2016-09-20
  6 in total

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