| Literature DB >> 24747088 |
Nan Liu1, Leili Jia1, Jiye Yin1, Zhihao Wu1, Zhongqiang Wang1, Peng Li1, Rongzhang Hao1, Ligui Wang1, Yong Wang1, Shaofu Qiu2, Hongbin Song3.
Abstract
In 2009, an outbreak of aseptic meningitis caused by coxsackievirus B5 (CVB5) occurred in China. Epidemiological investigations of this outbreak revealed that the proportion of severe cases (14/43, 33%) was higher than in other outbreaks associated with CVB5 in China. Phylogenetic analysis of the entire VP1 sequences demonstrated that the CVB5 isolates from the severe cases form a distinct lineage belonging to genogroup E with the Shandong isolates of 2009. A substitution of serine (S) to asparagine (N) at amino acid 95 in the VP1 region may be a major virulence determinant for the virus. Our findings suggest that this new lineage of CVB5 is circulating in China. Further genetic studies are needed in order to gain a better insight into the genetic variability of CVB5 isolates and the relationship with pathogenicity.Entities:
Keywords: Aseptic meningitis; Coxsackievirus B5; Genetically distinct; Outbreak; Substitution
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Year: 2014 PMID： 24747088 DOI： 10.1016/j.ijid.2014.02.005
Source DB: PubMed Journal: Int J Infect Dis ISSN： 1201-9712 Impact factor: 3.623