| Literature DB >> 24746899 |
Hailong Shi1, Jinling Jiang1, Jun Ji1, Min Shi1, Qu Cai1, Xuehua Chen1, Yingyan Yu1, Bingya Liu1, Zhenggang Zhu2, Jun Zhang3.
Abstract
Inhibitory effects and potential mechanisms of capecitabine metronomic chemotherapy on colon cancer were investigated in this study. Metronomic chemotherapy with fluorouracil or capecitabine inhibited proliferation of colon cancer cells both in vitro and in vivo. Capecitabine metronomic chemotherapy demonstrated equal effects as CTX metronomic chemotherapy. Metronomic capecitabine or CTX chemotherapy decreased vascular endothelial growth factor (VEGF) but elevated thrombospondin-1 (TSP-1) expression, reduced CEP levels and decreased microvessel density (MVD). These results indicated anti-angiogenesis may be correlated with the antitumor effects of metronomic capecitabine in colon cancer.Entities:
Keywords: Anti-angiogenesis; CTX; Capecitabine; Colorectal cancer; Metronomic chemotherapy
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Year: 2014 PMID： 24746899 DOI： 10.1016/j.canlet.2014.04.002
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679