Zhijian Yao1, Rui Yan2, Maobin Wei3, Hao Tang2, Jiaolong Qin3, Qing Lu4. 1. Department of Psychiatry, Affiliated Nanjing Brain Hospital of Nanjing Medical University, Nanjing 210029, China; Medical School, Nanjing University, Nanjing 210093, China. Electronic address: zjyao@njmu.edu.cn. 2. Department of Psychiatry, Affiliated Nanjing Brain Hospital of Nanjing Medical University, Nanjing 210029, China. 3. Research Center of Learning Science, Southeast University, Nanjing 210096, China. 4. Research Center of Learning Science, Southeast University, Nanjing 210096, China. Electronic address: luq@seu.edu.cn.
Abstract
OBJECTIVE: We examined the gender-difference effect on abnormal spontaneous neuronal activity of male and female major depressive disorder (MDD) patients using the amplitude of low-frequency fluctuation (ALFF) and the further clarified the relationship between the abnormal ALFF and differences in MDD prevalence rates between male and female patients. METHODS: Fourteen male MDD patients, 13 female MDD patients and 15 male and 15 female well matched healthy controls (HCs) completed this study. The ALFF approach was used, and Pearson correlation was conducted to observe a possible clinical relevance. RESULTS: There were widespread differences in ALFF values between female and male MDD patients, including some important parts of the frontoparietal network, auditory network, attention network and cerebellum network. In female MDD patients, there was a positive correlation between average ALFF values of the left postcentral gyrus and the severity of weight loss symptom. CONCLUSIONS: The gender-difference effect leading to abnormal brain activity is an important underlying pathomechanism for different somatic symptoms in MDD patients of different genders and is likely suggestive of higher MDD prevalence rates in females. SIGNIFICANCE: The abnormal ALFF resulting from the gender-difference effect might improve our understanding of the differences in prevalence rates between male and female MDD patients from another perspective.
OBJECTIVE: We examined the gender-difference effect on abnormal spontaneous neuronal activity of male and female major depressive disorder (MDD) patients using the amplitude of low-frequency fluctuation (ALFF) and the further clarified the relationship between the abnormal ALFF and differences in MDD prevalence rates between male and female patients. METHODS: Fourteen male MDDpatients, 13 female MDDpatients and 15 male and 15 female well matched healthy controls (HCs) completed this study. The ALFF approach was used, and Pearson correlation was conducted to observe a possible clinical relevance. RESULTS: There were widespread differences in ALFF values between female and male MDDpatients, including some important parts of the frontoparietal network, auditory network, attention network and cerebellum network. In female MDDpatients, there was a positive correlation between average ALFF values of the left postcentral gyrus and the severity of weight loss symptom. CONCLUSIONS: The gender-difference effect leading to abnormal brain activity is an important underlying pathomechanism for different somatic symptoms in MDDpatients of different genders and is likely suggestive of higher MDD prevalence rates in females. SIGNIFICANCE: The abnormal ALFF resulting from the gender-difference effect might improve our understanding of the differences in prevalence rates between male and female MDDpatients from another perspective.
Authors: L M Jenkins; A D Kendall; M T Kassel; V G Patrón; J R Gowins; C Dion; S A Shankman; S L Weisenbach; P Maki; S A Langenecker Journal: J Affect Disord Date: 2017-08-15 Impact factor: 4.839
Authors: Katharina Helm; Kathrin Viol; Thomas M Weiger; Peter A Tass; Christian Grefkes; Damir Del Monte; Günter Schiepek Journal: Neuropsychiatr Dis Treat Date: 2018-10-17 Impact factor: 2.570