Stefan Höfer1, Werner Benzer2, Neil Oldridge3. 1. Department of Medical Psychology, Innsbruck Medical University, Austria. Electronic address: stefan.hoefer@i-med.ac.at. 2. Department of Interventional Cardiology, Academic Hospital, Feldkirch, Austria. 3. College of Health Sciences, University of Wisconsin-Milwaukee, Milwaukee, WI, USA; Aurora Cardiovascular Services, Aurora St. Luke's Medical Center, Milwaukee, WI, USA.
Abstract
AIMS: Self-reported health-related quality of life (HRQL) and changes in HRQL have been shown to predict mortality and/or adverse events in patients with coronary artery disease. MacNew Heart Disease HRQL questionnaire scores were examined as predictors of 4-year all-cause mortality. METHODS: Following referral for angioplasty in 385 patients with coronary artery disease, data were analyzed for differences in all-cause mortality by MacNew Global and subscale baseline and 1- and 3-month change scores (deteriorated ≥0.50; unchanged (-0.49 to +0.49); and improved ≥0.50 points). RESULTS: Mean baseline, 1-month, and 3-month MacNew Global and subscale scores were similar in survivors and non-survivors. Mean 1- and 3-month Global and emotional subscale and mean 1-month social subscale change scores decreased more in non-survivors than survivors. Compared with patients whose Global MacNew HRQL scores improved at one month, 4-year all-cause mortality hazard ratio (HR) was higher in patients whose HRQL deteriorated (HR, 1.70, 95% CI, 1.09, 2.65; p=0.021). Compared with patients whose Global MacNew HRQL improved at three months, 4-year all-cause mortality was higher in both patients whose HRQL had deteriorated (HR, 2.07, 95% CI, 1.29, 3.32; p=0.003) and patients with unchanged HRQL (HR, 2.62, 95% CI, 1.11, 6.17; p=0.028). CONCLUSIONS: A deterioration of ≥0.50 points in MacNew HRQL Global scores at both one and three months is predictive of 4-year all-cause mortality. Serial HRQL information may be useful to identify patients at higher risk for adverse cardiac events and mortality and may have implications for determining follow-up frequency and treatment in individual patients.
AIMS: Self-reported health-related quality of life (HRQL) and changes in HRQL have been shown to predict mortality and/or adverse events in patients with coronary artery disease. MacNew Heart Disease HRQL questionnaire scores were examined as predictors of 4-year all-cause mortality. METHODS: Following referral for angioplasty in 385 patients with coronary artery disease, data were analyzed for differences in all-cause mortality by MacNew Global and subscale baseline and 1- and 3-month change scores (deteriorated ≥0.50; unchanged (-0.49 to +0.49); and improved ≥0.50 points). RESULTS: Mean baseline, 1-month, and 3-month MacNew Global and subscale scores were similar in survivors and non-survivors. Mean 1- and 3-month Global and emotional subscale and mean 1-month social subscale change scores decreased more in non-survivors than survivors. Compared with patients whose Global MacNew HRQL scores improved at one month, 4-year all-cause mortality hazard ratio (HR) was higher in patients whose HRQL deteriorated (HR, 1.70, 95% CI, 1.09, 2.65; p=0.021). Compared with patients whose Global MacNew HRQL improved at three months, 4-year all-cause mortality was higher in both patients whose HRQL had deteriorated (HR, 2.07, 95% CI, 1.29, 3.32; p=0.003) and patients with unchanged HRQL (HR, 2.62, 95% CI, 1.11, 6.17; p=0.028). CONCLUSIONS: A deterioration of ≥0.50 points in MacNew HRQL Global scores at both one and three months is predictive of 4-year all-cause mortality. Serial HRQL information may be useful to identify patients at higher risk for adverse cardiac events and mortality and may have implications for determining follow-up frequency and treatment in individual patients.
Authors: John W Liang; Ying Kuen Cheung; Joshua Z Willey; Yeseon P Moon; Ralph L Sacco; Mitchell S V Elkind; Mandip S Dhamoon Journal: Qual Life Res Date: 2017-03-29 Impact factor: 4.147
Authors: Mohammad Hossein Sharifi; Mohammad Hassan Eftekhari; Mohammad Ali Ostovan; Abbas Rezaianazadeh Journal: J Cardiovasc Thorac Res Date: 2017-03-06
Authors: Amir Vahedian-Azimi; Andrew C Miller; Mohammadreza Hajiesmaieli; Mari Kangasniemi; Fatemah Alhani; Hosseinali Jelvehmoghaddam; Mohammad Fathi; Behrooz Farzanegan; Seyed H Ardehali; Sevak Hatamian; Mehdi Gahremani; Seyed M M Mosavinasab; Zohreh Rostami; Seyed J Madani; Morteza Izadi Journal: Open Heart Date: 2016-04-19