| Literature DB >> 24746458 |
Weiqi Pan1, Ling Han2, Zhenyuan Dong3, Xuefeng Niu1, Zhengfeng Li3, Linlin Bao4, Chufang Li1, Qinfang Luo1, Zifeng Yang1, Xiaobo Li4, Jicheng Huang5, Liqiang Feng3, Chuan Qin4, Nanshan Zhong1, Ling Chen6.
Abstract
We evaluated the immunogenicity of hemagglutinin (HA) in the context of inactivated H7N9/AH/1/13-PR8 whole-virion. At 4weeks after immunization with 15μg HA, mice produced hemagglutination inhibition (HI) titers of 1:192 and neutralizing antibodies of 1:317. Aluminum hydroxide (alum), or a booster immunization, or both increased HI to 1:768, 1:384, 1:896 and neutralizing antibodies to 1:1868, 1:2302, 1:10,000, respectively. Macaques generated HI of 1:190 or 1:360 and virus neutralizing titers of 1:280 or 1:658 at 3weeks after immunization with HA alone or with alum. Sera from immunized mice and macaques protected mice from infection of A/Anhui/1/2013 (H7N9), suggesting an H7N9 vaccine is immunologically feasible.Entities:
Keywords: Antibody; H7N9; Hemagglutinin; Influenza; Neutralization
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Year: 2014 PMID： 24746458 DOI： 10.1016/j.antiviral.2014.04.003
Source DB: PubMed Journal: Antiviral Res ISSN： 0166-3542 Impact factor: 5.970