Jess G Fiedorowicz1, Dubravka Jancic2, James B Potash2, Brandon Butcher2, William H Coryell2. 1. Department of Psychiatry, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, IA; Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, IA; Department of Epidemiology, College of Public Health, The University of Iowa, Iowa City, IA. Electronic address: jess-fiedorowicz@uiowa.edu. 2. Department of Psychiatry, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, IA.
Abstract
BACKGROUND: In prior work, we identified a relationship between symptom burden and vascular outcomes in bipolar disorder. OBJECTIVE: We sought to replicate these findings using a readily accessible measure of mood disorder chronicity and vascular mortality. METHODS: We conducted a mortality assessment using the National Death Index for 1716 participants with bipolar I disorder from the National Institute of Mental Health Genetics Initiative Bipolar Disorder Consortium. We assessed the relationship between the duration of the most severe depressive and manic episodes and time to vascular mortality (cardiovascular or cerebrovascular) using Cox proportional hazards models, adjusting for potentially confounding variables. RESULTS: Mortality was assessed a mean for 7 years following study intake, at which time 58 participants died, 18 of vascular causes. These participants had depression for much longer than their counterparts did (Wilcoxon rank sum Z = 2.30, p = 0.02) and the duration of the longest depressive episode in years was significantly associated with time to vascular mortality in models (hazard ratio = 1.16, 95% confidence interval: 1.02-1.33, p = 0.02), which controlled for age, gender, vascular disease equivalents, and vascular disease risk factors. The duration of longest mania was not related to vascular mortality. CONCLUSION: The duration of the most severe depression is independently predictive of vascular mortality, lending further support to the idea that mood disorders hasten vascular mortality in a dose-dependent fashion. Further study of the relevant mechanisms by which mood disorders may hasten vascular disease and of integrated treatments for mood and cardiovascular risk factors is warranted.
BACKGROUND: In prior work, we identified a relationship between symptom burden and vascular outcomes in bipolar disorder. OBJECTIVE: We sought to replicate these findings using a readily accessible measure of mood disorder chronicity and vascular mortality. METHODS: We conducted a mortality assessment using the National Death Index for 1716 participants with bipolar I disorder from the National Institute of Mental Health Genetics Initiative Bipolar Disorder Consortium. We assessed the relationship between the duration of the most severe depressive and manic episodes and time to vascular mortality (cardiovascular or cerebrovascular) using Cox proportional hazards models, adjusting for potentially confounding variables. RESULTS: Mortality was assessed a mean for 7 years following study intake, at which time 58 participants died, 18 of vascular causes. These participants had depression for much longer than their counterparts did (Wilcoxon rank sum Z = 2.30, p = 0.02) and the duration of the longest depressive episode in years was significantly associated with time to vascular mortality in models (hazard ratio = 1.16, 95% confidence interval: 1.02-1.33, p = 0.02), which controlled for age, gender, vascular disease equivalents, and vascular disease risk factors. The duration of longest mania was not related to vascular mortality. CONCLUSION: The duration of the most severe depression is independently predictive of vascular mortality, lending further support to the idea that mood disorders hasten vascular mortality in a dose-dependent fashion. Further study of the relevant mechanisms by which mood disorders may hasten vascular disease and of integrated treatments for mood and cardiovascular risk factors is warranted.
Authors: Laura Manenschijn; Annet T Spijker; Jan W Koper; Andrea M Jetten; Erik J Giltay; Judith Haffmans; Erik Hoencamp; Elisabeth F C van Rossum Journal: Psychoneuroendocrinology Date: 2012-05-24 Impact factor: 4.905
Authors: Klara Latalova; Jan Prasko; Tomas Diveky; Ales Grambal; Dana Kamaradova; Hana Velartova; Jiri Salinger; Jaroslav Opavsky Journal: Neuro Endocrinol Lett Date: 2010 Impact factor: 0.765
Authors: Stephanie Nissen; Sherri Liang; Tatyana Shehktman; John R Kelsoe; Tiffany A Greenwood; Caroline M Nievergelt; Rebecca McKinney; Paul D Shilling; Erin N Smith; Nicholas J Schork; Cinnamon S Bloss; John I Nurnberger; Howard J Edenberg; Tatiana Foroud; Daniel L Koller; Elliot S Gershon; Chunyu Liu; Judith A Badner; William A Scheftner; William B Lawson; Evaristus A Nwulia; Maria Hipolito; William Coryell; John Rice; William Byerley; Francis J McMahon; Wade H Berrettini; James B Potash; Peter P Zandi; Pamela B Mahon; Melvin G McInnis; Sebastian Zöllner; Peng Zhang; David W Craig; Szabolics Szelinger; Thomas B Barrett; Thomas G Schulze Journal: Am J Med Genet B Neuropsychiatr Genet Date: 2012-10-04 Impact factor: 3.568
Authors: Kathleen R Merikangas; Hagop S Akiskal; Jules Angst; Paul E Greenberg; Robert M A Hirschfeld; Maria Petukhova; Ronald C Kessler Journal: Arch Gen Psychiatry Date: 2007-05
Authors: Jess G Fiedorowicz; William H Coryell; John P Rice; Lois L Warren; William G Haynes Journal: Psychother Psychosom Date: 2012-05-11 Impact factor: 17.659
Authors: Simrit K Sodhi; Jonathan Linder; Catherine A Chenard; Del D Miller; William G Haynes; Jess G Fiedorowicz Journal: J Psychosom Res Date: 2012-07-04 Impact factor: 3.006
Authors: Brian Tong; Oluchi Abosi; Samantha Schmitz; Janie Myers; Gary L Pierce; Jess G Fiedorowicz Journal: Gen Hosp Psychiatry Date: 2017-12-19 Impact factor: 3.238
Authors: Jess G Fiedorowicz; Alan R Prossin; Casey P Johnson; Gary E Christensen; Vincent A Magnotta; John A Wemmie Journal: J Affect Disord Date: 2015-08-21 Impact factor: 4.839
Authors: Jonathan W Birdsall; Samantha L Schmitz; Oluchi J Abosi; Lyndsey E DuBose; Gary L Pierce; Jess G Fiedorowicz Journal: Heart Mind (Mumbai) Date: 2019-11-25
Authors: Benjamin I Goldstein; Bernhard T Baune; David J Bond; Pao-Huan Chen; Lisa Eyler; Andrea Fagiolini; Fabiano Gomes; Tomas Hajek; Jessica Hatch; Susan L McElroy; Roger S McIntyre; Miguel Prieto; Louisa G Sylvia; Shang-Ying Tsai; Andrew Kcomt; Jess G Fiedorowicz Journal: Bipolar Disord Date: 2020-06-08 Impact factor: 6.744
Authors: Linn Rødevand; Shahram Bahrami; Oleksandr Frei; Yunhan Chu; Alexey Shadrin; Kevin S O'Connell; Olav B Smeland; Torbjørn Elvsåshagen; Guy F L Hindley; Srdjan Djurovic; Anders M Dale; Trine V Lagerberg; Nils Eiel Steen; Ole A Andreassen Journal: Transl Psychiatry Date: 2021-07-23 Impact factor: 6.222