Yoko Irie1, Naoto Katakami2, Hideaki Kaneto1, Mitsuyoshi Takahara1, Ken'ya Sakamoto3, Keisuke Kosugi3, Iichiro Shimomura1. 1. Department of Metabolic Medicine, Osaka University Graduate School of Medicine. 2. Department of Metabolic Medicine, Osaka University Graduate School of Medicine; Department of Metabolism and Atherosclerosis, Osaka University Graduate School of Medicine. Electronic address: katakami@endmet.med.osaka-u.ac.jp. 3. Osaka Police Hospital.
Abstract
AIMS: Little is known about the related factors of plaque echogenicity in diabetic subjects. METHODS: This was a single-center, retrospective, study investigating a subgroup of patients of a previously published trial. We enrolled 179 middle-aged and older Japanese type 2 diabetic patients with carotid plaque, and examined the parameters related with echogenicity of carotid plaque evaluated by gray-scale median (GSM). RESULTS: Proportion of males and body mass index (BMI) were significantly higher and HDL-cholesterol was significantly lower in the patients with low GSM (< 48) plaques (n = 89) as compared to those without it (n = 90). A multiple logistic regression analysis with gender, BMI, and HDL-cholesterol as independent variables and the presence of low GSM plaques as an objective variable showed that male (odds ratio (OR) 2.36, 95%CI 1.05-5.31, p = 0.037) and BMI (OR 1.12 [1.01-1.24], p = 0.029) were independently associated with low GSM plaques. Another multiple logistic regression analysis with gender, BMI, and low-HDL-cholesterolemia (HDL-C < 40 mg/dl) as independent variables showed that low-HDL-cholesterolemia (OR 2.30 [1.03-5.13], p = 0.042) and BMI (OR 1.11 [1.00-1.22], p = 0.046) were independently associated with low GSM plaques. CONCLUSIONS: Our study suggests that gender, BMI and low-HDL-cholesterol are important determinants of the content of the vascular wall in diabetic subjects.
AIMS: Little is known about the related factors of plaque echogenicity in diabetic subjects. METHODS: This was a single-center, retrospective, study investigating a subgroup of patients of a previously published trial. We enrolled 179 middle-aged and older Japanese type 2 diabeticpatients with carotid plaque, and examined the parameters related with echogenicity of carotid plaque evaluated by gray-scale median (GSM). RESULTS: Proportion of males and body mass index (BMI) were significantly higher and HDL-cholesterol was significantly lower in the patients with low GSM (< 48) plaques (n = 89) as compared to those without it (n = 90). A multiple logistic regression analysis with gender, BMI, and HDL-cholesterol as independent variables and the presence of low GSM plaques as an objective variable showed that male (odds ratio (OR) 2.36, 95%CI 1.05-5.31, p = 0.037) and BMI (OR 1.12 [1.01-1.24], p = 0.029) were independently associated with low GSM plaques. Another multiple logistic regression analysis with gender, BMI, and low-HDL-cholesterolemia (HDL-C < 40 mg/dl) as independent variables showed that low-HDL-cholesterolemia (OR 2.30 [1.03-5.13], p = 0.042) and BMI (OR 1.11 [1.00-1.22], p = 0.046) were independently associated with low GSM plaques. CONCLUSIONS: Our study suggests that gender, BMI and low-HDL-cholesterol are important determinants of the content of the vascular wall in diabetic subjects.
Authors: Carol Mitchell; Megan E Piper; Claudia E Korcarz; Kristin Hansen; JoAnne Weber; Michael C Fiore; Timothy B Baker; James H Stein Journal: J Diagn Med Sonogr Date: 2017-12-19
Authors: Aditya M Sharma; Ajay Gupta; P Krishna Kumar; Jeny Rajan; Luca Saba; Ikeda Nobutaka; John R Laird; Andrew Nicolades; Jasjit S Suri Journal: Curr Atheroscler Rep Date: 2015-09 Impact factor: 5.113