N Mahalle1, M V Kulkarni2, S S Naik3, M K Garg4. 1. Deenanath Mangeshkar Hospital and Research Center, Biochemistry Section, Department of Pathology, Erandawane, Pune-411004, India; Department of Endocrinology, Command Hospital (Southern Command), Pune. Electronic address: pnmahalle@gmail.com. 2. Division of Biochemistry, Department of Chemistry, University of Pune. 3. Deenanath Mangeshkar Hospital and Research Center, Biochemistry Section, Department of Pathology, Erandawane, Pune-411004, India; Department of Endocrinology, Command Hospital (Southern Command), Pune. 4. Department of Endocrinology, Command Hospital (Southern Command), Pune.
Abstract
BACKGROUND: Insulin resistance (IR) and inflammation have been implicated in pathogenesis of diabetes and cardiovascular disease. Dietary factors have been reported to be associated to insulin resistance and inflammation. Hence, we studied the association of dietary factors with IR and inflammation in known patients with diabetes mellitus and coronary artery disease with the hypothesis that carbohydrate and fat will be positively; and protein, fiber and mineral will be negatively associated with IR and inflammatory markers. METHODS: Three hundred patients (M: 216; F: 84, age: 25-92) who had coronary disease on angiography were included in this study consecutively. All patients were evaluated for anthropometry and cardiovascular risk factors, and blood samples were collected for biochemical and inflammatory markers. Nutrition assessment was done once at the time of recruitment, based on 24h dietary recall. RESULTS AND CONCLUSIONS: Diabetic patients had significantly lower protein and total dietary fiber intake as compared to non diabetics. Diabetic patients had lower intake of vitamin A, riboflavin and vitamin B12. There was significantly lower intake of minerals by diabetic patients. Dietary carbohydrate and fat were positively, and protein and dietary fiber intakes were negatively correlated with HOMA-IR and IL-6. There was no correlation of individual amino acids with HOMA-IR but showed strong negative correlation with inflammatory markers (hsCRP; IL-6 and TNF-α). Intake of vitamins and minerals was negatively correlated with HOMA-IR and inflammatory markers. There is a strong correlation between dietary factors, insulin resistance and inflammatory markers.
BACKGROUND:Insulin resistance (IR) and inflammation have been implicated in pathogenesis of diabetes and cardiovascular disease. Dietary factors have been reported to be associated to insulin resistance and inflammation. Hence, we studied the association of dietary factors with IR and inflammation in known patients with diabetes mellitus and coronary artery disease with the hypothesis that carbohydrate and fat will be positively; and protein, fiber and mineral will be negatively associated with IR and inflammatory markers. METHODS: Three hundred patients (M: 216; F: 84, age: 25-92) who had coronary disease on angiography were included in this study consecutively. All patients were evaluated for anthropometry and cardiovascular risk factors, and blood samples were collected for biochemical and inflammatory markers. Nutrition assessment was done once at the time of recruitment, based on 24h dietary recall. RESULTS AND CONCLUSIONS:Diabeticpatients had significantly lower protein and total dietary fiber intake as compared to non diabetics. Diabeticpatients had lower intake of vitamin A, riboflavin and vitamin B12. There was significantly lower intake of minerals by diabeticpatients. Dietary carbohydrate and fat were positively, and protein and dietary fiber intakes were negatively correlated with HOMA-IR and IL-6. There was no correlation of individual amino acids with HOMA-IR but showed strong negative correlation with inflammatory markers (hsCRP; IL-6 and TNF-α). Intake of vitamins and minerals was negatively correlated with HOMA-IR and inflammatory markers. There is a strong correlation between dietary factors, insulin resistance and inflammatory markers.
Authors: Jasmine F Plows; Florence Budin; Rebecka A M Andersson; Valerie J Mills; Katherine Mace; Sandra T Davidge; Mark H Vickers; Philip N Baker; Irma Silva-Zolezzi; Joanna L Stanley Journal: Nutrients Date: 2017-02-15 Impact factor: 5.717
Authors: Camilo P Martínez-Reyes; Angélica Y Gómez-Arauz; Israel Torres-Castro; Aarón N Manjarrez-Reyna; León F Palomera; Alfonso Olivos-García; Edith Mendoza-Tenorio; Gabriela A Sánchez-Medina; Sergio Islas-Andrade; Guillermo Melendez-Mier; Galileo Escobedo Journal: J Diabetes Res Date: 2018-02-21 Impact factor: 4.011