| Literature DB >> 24746291 |
Marcela Amaral Avelino1, Eduardo Ferracioli Fusão2, José Luiz Pedroso2, Juliana Harumi Arita2, Reinaldo Teixeira Ribeiro2, Ricardo Silva Pinho2, Karin Tuschl3, Orlando G P Barsottini2, Marcelo Rodrigues Masruha2.
Abstract
Manganese (Mn) toxicity causes an extrapyramidal, parkinsonian-type movement disorder with characteristic magnetic resonance images of Mn accumulation in the basal ganglia. This letter highlights the neurological manifestations and neuroimaging features of inherited manganism (IMn), an unusual and treatable inborn error of Mn homeostasis. Early-onset dystonia with "cock-walk" gait and hyperintense signal in basal ganglia, associated to polycythemia, chronic liver disease and hypermanganesemia, promptly suggest IMn, and a genetic evaluation should be performed.Entities:
Keywords: Dystonia; Hypermanganesemia; Manganese; Manganism inherited; Movement disorders
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Year: 2014 PMID： 24746291 DOI： 10.1016/j.jns.2014.03.057
Source DB: PubMed Journal: J Neurol Sci ISSN： 0022-510X Impact factor: 3.181