| Literature DB >> 24745681 |
Maurizio Rossini1, Roberta Zanotti2, Ombretta Viapiana2, Gaia Tripi2, Giovanni Orsolini2, Luca Idolazzi2, Patrizia Bonadonna2, Donatella Schena2, Luis Escribano2, Silvano Adami2, Davide Gatti2.
Abstract
Bone involvement is frequent in patients with systemic mastocytosis. Osteoporosis is the most prevalent bone manifestation, but diffuse osteosclerosis or focal osteolytic or osteosclerotic lesions are not infrequent. The risk of osteoporotic fractures is high, especially at the spine and in men. Routine measurements of bone mineral density and vertebral morphometry are warranted. The bone turnover markers indicate the involvement of complex bone metabolism in mastocytosis-related manifestations. Bisphosphonates represent the first-line treatment for osteoporosis-related mastocytosis.Entities:
Keywords: Bone mineral density; Bone turnover markers; Fracture; Mastocytosis; Osteoporosis; Osteosclerosis
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Year: 2014 PMID: 24745681 DOI: 10.1016/j.iac.2014.01.011
Source DB: PubMed Journal: Immunol Allergy Clin North Am ISSN: 0889-8561 Impact factor: 3.479