Literature DB >> 24745610

Apoptosis-inducing effects of Melissa officinalis L. essential oil in glioblastoma multiforme cells.

Rafaela Muniz de Queiroz1, Christina Maeda Takiya, Lívia Paes Tavares Pacheco Guimarães, Gleice da Graça Rocha, Daniela Sales Alviano, Arie Fitzgerald Blank, Celuta Sales Alviano, Cerli Rocha Gattass.   

Abstract

Current therapies for glioblastoma multiforme (GBM) are not effective. This study investigated the activity of the M. officinalis essential oil (EO) and its major component (citral) in GBM cell lines. Both EO and citral decreased the viability and induced apoptosis of GBM cells as demonstrated by DNA fragmentation and caspase-3 activation. Antioxidant prevented citral-induced death, indicating its dependence on the production of reactive oxygen species. Citral downmodulated the activity and inhibited the expression of multidrug resistance associated protein 1 (MRP1). These results show that EO, through its major component, citral, may be of potential interest for the treatment of GBM.

Entities:  

Keywords:  Chemotherapy; Citral; Gliobastoma multiforme; Melissa officinali essential oil

Mesh：

Substances：

Year:  2014        PMID： 24745610     DOI： 10.3109/07357907.2014.905587

Source DB:  PubMed          Journal:  Cancer Invest        ISSN： 0735-7907            Impact factor:   2.176


  8 in total

Review 1.  Biological Activities of Essential Oils: From Plant Chemoecology to Traditional Healing Systems.

Authors:  Javad Sharifi-Rad; Antoni Sureda; Gian Carlo Tenore; Maria Daglia; Mehdi Sharifi-Rad; Marco Valussi; Rosa Tundis; Marzieh Sharifi-Rad; Monica R Loizzo; Adedayo Oluwaseun Ademiluyi; Razieh Sharifi-Rad; Seyed Abdulmajid Ayatollahi; Marcello Iriti
Journal:  Molecules       Date:  2017-01-01       Impact factor: 4.411

2.  Changes in O-Linked N-Acetylglucosamine (O-GlcNAc) Homeostasis Activate the p53 Pathway in Ovarian Cancer Cells.

Authors:  Rafaela Muniz de Queiroz; Rashna Madan; Jeremy Chien; Wagner Barbosa Dias; Chad Slawson
Journal:  J Biol Chem       Date:  2016-07-11       Impact factor: 5.157

Review 3.  Exploitation of cytotoxicity of some essential oils for translation in cancer therapy.

Authors:  Rossella Russo; Maria Tiziana Corasaniti; Giacinto Bagetta; Luigi Antonio Morrone
Journal:  Evid Based Complement Alternat Med       Date:  2015-02-04       Impact factor: 2.629

4.  Lemon Grass Essential Oil Does not Modulate Cancer Cells Multidrug Resistance by Citral-Its Dominant and Strongly Antimicrobial Compound.

Authors:  Jitka Viktorová; Michal Stupák; Kateřina Řehořová; Simona Dobiasová; Lan Hoang; Jana Hajšlová; Tran Van Thanh; Le Van Tri; Nguyen Van Tuan; Tomáš Ruml
Journal:  Foods       Date:  2020-05-05

5.  Lemon Balm Extracts Prevent Breast Cancer Progression In Vitro and In Ovo on Chorioallantoic Membrane Assay.

Authors:  Roxana Ghiulai; Stefana Avram; Dana Stoian; Ioana Zinuca Pavel; Dorina Coricovac; Camelia Oprean; Laurian Vlase; Claudia Farcas; Marius Mioc; Daliana Minda; Andrei Motoc; Camelia Szuhanek; Corina Danciu; Codruta Soica; Laurentiu Sima
Journal:  Evid Based Complement Alternat Med       Date:  2020-04-14       Impact factor: 2.629

6.  Melissa officinalis Extract Induces Apoptosis and Inhibits Migration in Human Colorectal Cancer Cells.

Authors:  Tzu-Ting Kuo; Hsin-Yi Chang; Tai-Yuan Chen; Bai-Chia Liu; Hsin-Yi Chen; Yuan-Chin Hsiung; Shih-Min Hsia; Chun-Ju Chang; Tsui-Chin Huang
Journal:  ACS Omega       Date:  2020-12-03

7.  Elucidating the Anti-Tumorigenic Efficacy of Oltipraz, a Dithiolethione, in Glioblastoma.

Authors:  Upasana Kapoor-Narula; Nibedita Lenka
Journal:  Cells       Date:  2022-09-29       Impact factor: 7.666

Review 8.  Anticancer Properties of Essential Oils and Other Natural Products.

Authors:  K Blowman; M Magalhães; M F L Lemos; C Cabral; I M Pires
Journal:  Evid Based Complement Alternat Med       Date:  2018-03-25       Impact factor: 2.629
  8 in total

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