Literature DB >> 24745326

The emerging landscape of RORγt biology.

Jacob S Lee1, Daniel J Cua2.   

Abstract

The transcription factor retinoid-related orphan receptor gamma t (RORγt) has emerged as an exciting target for inflammatory diseases. Xiao et al. (2014) show that a new class of RORγt antagonists can inhibit the inflammatory function of T helper 17 cells without altering RORγt occupancy on its target genes.
Copyright © 2014 Elsevier Inc. All rights reserved.

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Year:  2014        PMID： 24745326     DOI： 10.1016/j.immuni.2014.04.005

Source DB:  PubMed          Journal:  Immunity        ISSN： 1074-7613            Impact factor:   31.745


  5 in total

Review 1.  The IL-23-IL-17 immune axis: from mechanisms to therapeutic testing.

Authors:  Sarah L Gaffen; Renu Jain; Abhishek V Garg; Daniel J Cua
Journal:  Nat Rev Immunol       Date:  2014-09       Impact factor: 53.106

2.  Discovery of BMS-986251: A Clinically Viable, Potent, and Selective RORγt Inverse Agonist.

Authors:  Robert J Cherney; Lyndon A M Cornelius; Anurag Srivastava; Carolyn A Weigelt; David Marcoux; James J-W Duan; Qing Shi; Douglas G Batt; Qingjie Liu; Shiuhang Yip; Dauh-Rurng Wu; Max Ruzanov; John Sack; Javed Khan; Jinhong Wang; Melissa Yarde; Mary Ellen Cvijic; Arvind Mathur; Sha Li; David Shuster; Purnima Khandelwal; Virna Borowski; Jenny Xie; Mary Obermeier; Aberra Fura; Kevin Stefanski; Georgia Cornelius; Joseph A Tino; John E Macor; Luisa Salter-Cid; Rex Denton; Qihong Zhao; Percy H Carter; T G Murali Dhar
Journal:  ACS Med Chem Lett       Date:  2020-03-31       Impact factor: 4.345

3.  Molecular dynamics simulations on RORγt: insights into its functional agonism and inverse agonism.

Authors:  Cong-Min Yuan; Hai-Hong Chen; Nan-Nan Sun; Xiao-Jun Ma; Jun Xu; Wei Fu
Journal:  Acta Pharmacol Sin       Date:  2019-07-17       Impact factor: 6.150

4.  Discovery of Biaryl Amides as Potent, Orally Bioavailable, and CNS Penetrant RORγt Inhibitors.

Authors:  Yonghui Wang; Wei Cai; Yaobang Cheng; Ting Yang; Qian Liu; Guifeng Zhang; Qinghua Meng; Fangbin Han; Yafei Huang; Ling Zhou; Zhijun Xiang; Yong-Gang Zhao; Yan Xu; Ziqiang Cheng; Sijie Lu; Qianqian Wu; Jia-Ning Xiang; John D Elliott; Stewart Leung; Feng Ren; Xichen Lin
Journal:  ACS Med Chem Lett       Date:  2015-05-26       Impact factor: 4.345

5.  Azatricyclic Inverse Agonists of RORγt That Demonstrate Efficacy in Models of Rheumatoid Arthritis and Psoriasis.

Authors:  Qingjie Liu; Hai-Yun Xiao; Douglas G Batt; Zili Xiao; Yeheng Zhu; Michael G Yang; Ning Li; Shiuhang Yip; Peng Li; Dawn Sun; Dauh-Rurng Wu; Max Ruzanov; John S Sack; Carolyn A Weigelt; Jinhong Wang; Sha Li; David J Shuster; Jenny H Xie; Yunling Song; Tara Sherry; Mary T Obermeier; Aberra Fura; Kevin Stefanski; Georgia Cornelius; Silvi Chacko; Purnima Khandelwal; Shailesh Dudhgaonkar; Anjuman Rudra; Jignesh Nagar; Venkata Murali; Arun Govindarajan; Rex Denton; Qihong Zhao; Nicholas A Meanwell; Robert Borzilleri; T G Murali Dhar
Journal:  ACS Med Chem Lett       Date:  2021-04-30       Impact factor: 4.345
  5 in total

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