Literature DB >> 24744979

Modulating antigen processing for cancer immunotherapy.

Efstratios Stratikos1.   

Abstract

The intracellular aminopeptidases that process antigenic epitopes have been recently shown to be valid targets for eliciting cell-mediated antitumor immune responses. Here, we discuss the recent development of potent, low molecular weight inhibitors of these enzymes and how such compounds may constitute a promising tool for cancer immunotherapy.

Entities:  

Keywords:  antigen; cytotoxicity; enzyme; epitope; immunotherapy; inhibitor; peptide; presentation

Year:  2014        PMID： 24744979      PMCID： PMC3989297          DOI： 10.4161/onci.27568

Source DB:  PubMed          Journal:  Oncoimmunology        ISSN： 2162-4011            Impact factor:   8.110


  10 in total

Review 1.  Escape of human solid tumors from T-cell recognition: molecular mechanisms and functional significance.

Authors:  F M Marincola; E M Jaffee; D J Hicklin; S Ferrone
Journal:  Adv Immunol       Date:  2000       Impact factor: 3.543

2.  Endoplasmic reticulum aminopeptidase 1 (ERAP1) trims MHC class I-presented peptides in vivo and plays an important role in immunodominance.

Authors:  Ian A York; Michael A Brehm; Sophia Zendzian; Charles F Towne; Kenneth L Rock
Journal:  Proc Natl Acad Sci U S A       Date:  2006-06-05       Impact factor: 11.205

3.  Altered expression of endoplasmic reticulum aminopeptidases ERAP1 and ERAP2 in transformed non-lymphoid human tissues.

Authors:  Doriana Fruci; Patrizio Giacomini; Maria R Nicotra; Matteo Forloni; Rocco Fraioli; Loredana Saveanu; Peter van Endert; Pier Giorgio Natali
Journal:  J Cell Physiol       Date:  2008-09       Impact factor: 6.384

Review 4.  Immune surveillance for ERAAP dysfunction.

Authors:  Niranjana A Nagarajan; Nilabh Shastri
Journal:  Mol Immunol       Date:  2013-02-20       Impact factor: 4.407

Review 5.  Antigenic peptide trimming by ER aminopeptidases--insights from structural studies.

Authors:  Efstratios Stratikos; Lawrence J Stern
Journal:  Mol Immunol       Date:  2013-03-29       Impact factor: 4.407

6.  Natural killer cells efficiently reject lymphoma silenced for the endoplasmic reticulum aminopeptidase associated with antigen processing.

Authors:  Loredana Cifaldi; Elisa Lo Monaco; Matteo Forloni; Ezio Giorda; Silvia Lorenzi; Stefania Petrini; Elisa Tremante; Daniela Pende; Franco Locatelli; Patrizio Giacomini; Doriana Fruci
Journal:  Cancer Res       Date:  2011-01-20       Impact factor: 12.701

7.  Distinct molecular mechanisms leading to deficient expression of ER-resident aminopeptidases in melanoma.

Authors:  Esther Kamphausen; Christiane Kellert; Tarish Abbas; Nadja Akkad; Stefan Tenzer; Graham Pawelec; Hansjoerg Schild; Peter van Endert; Barbara Seliger
Journal:  Cancer Immunol Immunother       Date:  2010-04-24       Impact factor: 6.968

8.  Induction of protective antitumor immunity through attenuation of ERAAP function.

Authors:  Edward James; Ian Bailey; Gessa Sugiyarto; Tim Elliott
Journal:  J Immunol       Date:  2013-04-22       Impact factor: 5.422

9.  Novel selective inhibitors of aminopeptidases that generate antigenic peptides.

Authors:  Athanasios Papakyriakou; Efthalia Zervoudi; Emmanuel A Theodorakis; Loredana Saveanu; Efstratios Stratikos; Dionisios Vourloumis
Journal:  Bioorg Med Chem Lett       Date:  2013-07-23       Impact factor: 2.823

10.  Rationally designed inhibitor targeting antigen-trimming aminopeptidases enhances antigen presentation and cytotoxic T-cell responses.

Authors:  Efthalia Zervoudi; Emmanuel Saridakis; James R Birtley; Sergey S Seregin; Emma Reeves; Paraskevi Kokkala; Yasser A Aldhamen; Andrea Amalfitano; Irene M Mavridis; Edward James; Dimitris Georgiadis; Efstratios Stratikos
Journal:  Proc Natl Acad Sci U S A       Date:  2013-11-18       Impact factor: 11.205
  10 in total
  13 in total

1.  Screening Identifies Thimerosal as a Selective Inhibitor of Endoplasmic Reticulum Aminopeptidase 1.

Authors:  Athanasios Stamogiannos; Athanasios Papakyriakou; Francois-Xavier Mauvais; Peter van Endert; Efstratios Stratikos
Journal:  ACS Med Chem Lett       Date:  2016-05-31       Impact factor: 4.345

2.  Editing the immunopeptidome of melanoma cells using a potent inhibitor of endoplasmic reticulum aminopeptidase 1 (ERAP1).

Authors:  Despoina Koumantou; Eilon Barnea; Adrian Martin-Esteban; Zachary Maben; Athanasios Papakyriakou; Anastasia Mpakali; Paraskevi Kokkala; Harris Pratsinis; Dimitris Georgiadis; Lawrence J Stern; Arie Admon; Efstratios Stratikos
Journal:  Cancer Immunol Immunother       Date:  2019-06-20       Impact factor: 6.968

3.  Critical Role of Interdomain Interactions in the Conformational Change and Catalytic Mechanism of Endoplasmic Reticulum Aminopeptidase 1.

Authors:  Athanasios Stamogiannos; Zachary Maben; Athanasios Papakyriakou; Anastasia Mpakali; Paraskevi Kokkala; Dimitris Georgiadis; Lawrence J Stern; Efstratios Stratikos
Journal:  Biochemistry       Date:  2017-03-02       Impact factor: 3.162

4.  Mechanism for antigenic peptide selection by endoplasmic reticulum aminopeptidase 1.

Authors:  Petros Giastas; Anastasia Mpakali; Athanasios Papakyriakou; Aggelos Lelis; Paraskevi Kokkala; Margarete Neu; Paul Rowland; John Liddle; Dimitris Georgiadis; Efstratios Stratikos
Journal:  Proc Natl Acad Sci U S A       Date:  2019-12-16       Impact factor: 11.205

5.  Mice expressing human ERAP1 variants associated with ankylosing spondylitis have altered T-cell repertoires and NK cell functions, as well as increased in utero and perinatal mortality.

Authors:  David P W Rastall; Fadel S Alyaquob; Patrick O'Connell; Yuliya Pepelyayeva; Douglas Peters; Sarah Godbehere-Roosa; Cristiane Pereira-Hicks; Yasser A Aldhamen; Andrea Amalfitano
Journal:  Int Immunol       Date:  2017-06-01       Impact factor: 4.823

6.  Single-Molecule RNA Sequencing Reveals IFNγ-Induced Differential Expression of Immune Escape Genes in Merkel Cell Polyomavirus-Positive MCC Cell Lines.

Authors:  Tatjana Sauerer; Christopher Lischer; Adrian Weich; Carola Berking; Julio Vera; Jan Dörrie
Journal:  Front Microbiol       Date:  2021-12-22       Impact factor: 5.640

7.  A systematic re-examination of processing of MHCI-bound antigenic peptide precursors by endoplasmic reticulum aminopeptidase 1.

Authors:  George Mavridis; Richa Arya; Alexander Domnick; Jerome Zoidakis; Manousos Makridakis; Antonia Vlahou; Anastasia Mpakali; Angelos Lelis; Dimitris Georgiadis; Robert Tampé; Athanasios Papakyriakou; Lawrence J Stern; Efstratios Stratikos
Journal:  J Biol Chem       Date:  2020-03-17       Impact factor: 5.157

8.  High Tumor Mutation Burden and Other Immunotherapy Response Predictors in Breast Cancers: Associations and Therapeutic Opportunities.

Authors:  Ioannis A Voutsadakis
Journal:  Target Oncol       Date:  2020-02       Impact factor: 4.864

9.  Aminobenzosuberone Scaffold as a Modular Chemical Tool for the Inhibition of Therapeutically Relevant M1 Aminopeptidases.

Authors:  Emmanuel Salomon; Marjorie Schmitt; Anil Kumar Marapaka; Athanasios Stamogiannos; Germain Revelant; Céline Schmitt; Sarah Alavi; Isabelle Florent; Anthony Addlagatta; Efstratios Stratikos; Céline Tarnus; Sébastien Albrecht
Journal:  Molecules       Date:  2018-10-11       Impact factor: 4.411

10.  Common allotypes of ER aminopeptidase 1 have substrate-dependent and highly variable enzymatic properties.

Authors:  Jonathan P Hutchinson; Ioannis Temponeras; Jonas Kuiper; Adrian Cortes; Justyna Korczynska; Semra Kitchen; Efstratios Stratikos
Journal:  J Biol Chem       Date:  2021-02-19       Impact factor: 5.157
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.