BACKGROUND: Potentially inappropriate prescriptions (PIP) are frequent, generate negative outcomes, and are to a great extent avoidable. Although there is general agreement about the definition of PIP, how to measure them is a matter of debate. OBJECTIVE: Our aim was to measure the frequency of PIP in older people at hospital discharge using two sets of criteria--Beers (2012 update) and STOPP. SETTING: A university hospital in southern Spain. METHOD: This cross sectional study involved a random sample of patients 65 years or more discharged from the University Hospital San Cecilio (Granada, Spain), from July 1, 2011 to June 30, 2012. Age, gender, length of hospital stay, type of hospital service, drugs prescribed and pathologies were obtained from discharge reports. MAIN OUTCOME MEASURE: The main outcome measures were: (1) the prevalence of PIP according to each set of criteria (Beers and STOPP) and its 95 % confidence interval, globally and stratified for different categories of the study variables; (2) the degree of agreement between the two criteria using Kappa statistics; and (3) the drugs most commonly involved in PIP according to both criteria. RESULTS: There were 624 patients (median age 78) included in our study. According to Beers criteria, 22.9 % (19.6-26.2 %) of the patients had at least one PIP. This figure was 38.4 % (34.6-42.2 %) for STOPP criteria. Just 13.6 % of the patients had prescriptions simultaneously inappropriate for both criteria. Higher PIP frequency was observed in patients discharged from internal medicine. PIP increased with the Charlson Index and with the number of drugs prescribed, but not with gender, age or length of hospital stay. CONCLUSION: A very high frequency of PIP at discharge was observed. By intervening in five drug groups, about 80 % of PIP might be avoided according to either of the two criteria.
BACKGROUND: Potentially inappropriate prescriptions (PIP) are frequent, generate negative outcomes, and are to a great extent avoidable. Although there is general agreement about the definition of PIP, how to measure them is a matter of debate. OBJECTIVE: Our aim was to measure the frequency of PIP in older people at hospital discharge using two sets of criteria--Beers (2012 update) and STOPP. SETTING: A university hospital in southern Spain. METHOD: This cross sectional study involved a random sample of patients 65 years or more discharged from the University Hospital San Cecilio (Granada, Spain), from July 1, 2011 to June 30, 2012. Age, gender, length of hospital stay, type of hospital service, drugs prescribed and pathologies were obtained from discharge reports. MAIN OUTCOME MEASURE: The main outcome measures were: (1) the prevalence of PIP according to each set of criteria (Beers and STOPP) and its 95 % confidence interval, globally and stratified for different categories of the study variables; (2) the degree of agreement between the two criteria using Kappa statistics; and (3) the drugs most commonly involved in PIP according to both criteria. RESULTS: There were 624 patients (median age 78) included in our study. According to Beers criteria, 22.9 % (19.6-26.2 %) of the patients had at least one PIP. This figure was 38.4 % (34.6-42.2 %) for STOPP criteria. Just 13.6 % of the patients had prescriptions simultaneously inappropriate for both criteria. Higher PIP frequency was observed in patients discharged from internal medicine. PIP increased with the Charlson Index and with the number of drugs prescribed, but not with gender, age or length of hospital stay. CONCLUSION: A very high frequency of PIP at discharge was observed. By intervening in five drug groups, about 80 % of PIP might be avoided according to either of the two criteria.
Authors: Jennifer Kirwin; Ann E Canales; Michael L Bentley; Kathy Bungay; Tammy Chan; Erica Dobson; Renee M Holder; Daniel Johnson; Andrea Lilliston; Rima A Mohammad; Sarah A Spinler Journal: Pharmacotherapy Date: 2012-10-26 Impact factor: 4.705
Authors: Eva Delgado Silveira; María Muñoz García; Beatriz Montero Errasquin; Carmen Sánchez Castellano; Paul F Gallagher; Alfonso J Cruz-Jentoft Journal: Rev Esp Geriatr Gerontol Date: 2009-06-21
Authors: Filipa Alves da Costa; Catarina Periquito; Maria Clara Carneiro; Pedro Oliveira; Ana Isabel Fernandes; Patrícia Cavaco-Silva Journal: Int J Clin Pharm Date: 2016-06-24
Authors: C A K van der Stelt; A M A Vermeulen Windsant-van den Tweel; A C G Egberts; P M L A van den Bemt; A J Leendertse; W A J J Hermens; R J van Marum; H J Derijks Journal: Drug Saf Date: 2016-01 Impact factor: 5.606