Literature DB >> 24743920

[Treatment of syncope].

D Andresen1.   

Abstract

The therapy of patients with syncope is oriented to the underlying pathophysiological mechanisms. Patients with reflex syncope require careful education regarding recognition of warning signs and the avoidance of trigger factors. Treatment with beta blockers is nowadays obsolete. Even other drugs have failed to show any benefit. Pacemaker therapy should only be considered if syncope attacks are frequent and if there is a correlation between symptoms and the electrocardiogram (ECG). Because autonomic failure in patients with orthostatic hypotension is often drug-induced, reduction of the dosage or the complete elimination is the treatment of choice in these patients. A higher than normal salt and fluid intake as well as general measures to avoid delayed venous backflow, e.g. elastic stockings, may also be helpful. A change in blood pressure medication can be decisive for therapy success, especially in elderly patients with arterial hypertension. Pacemaker and defibrillator therapy is the treatment of choice in patients with bradycardia and tachycardia arrhythmias, respectively. Although these measures are simple but effective, in individual cases it is still difficult to find clinical proof that arrhythmic disorders are the causal factors for the syncope. However, also in these patients cardiac pacing should be based on a symptom ECG correlation. The recently conducted market release of the injectable miniaturized ECG recorder will alleviate the diagnostic process. The limits of this approach, however, become obvious when there is the suspicion of a life-threatening rhythm disorder, because the only difference between syncope and sudden cardiac death is that in one case the patient wakes up again.

Entities:  

Mesh:

Year:  2014        PMID: 24743920     DOI: 10.1007/s00059-014-4096-z

Source DB:  PubMed          Journal:  Herz        ISSN: 0340-9937            Impact factor:   1.443


  28 in total

1.  NONSURGICAL ACQUIRED HEART BLOCK.

Authors:  C K FRIEDBERG; E DONOSO; W G STEIN
Journal:  Ann N Y Acad Sci       Date:  1964-06-11       Impact factor: 5.691

2.  The North American Vasovagal Pacemaker Study (VPS). A randomized trial of permanent cardiac pacing for the prevention of vasovagal syncope.

Authors:  S J Connolly; R Sheldon; R S Roberts; M Gent
Journal:  J Am Coll Cardiol       Date:  1999-01       Impact factor: 24.094

3.  Effectiveness of physical counterpressure maneuvers in preventing vasovagal syncope: the Physical Counterpressure Manoeuvres Trial (PC-Trial).

Authors:  Nynke van Dijk; Fabio Quartieri; Jean-Jaques Blanc; Roberto Garcia-Civera; Michele Brignole; Angel Moya; Wouter Wieling
Journal:  J Am Coll Cardiol       Date:  2006-09-26       Impact factor: 24.094

4.  Prevention of Syncope Trial (POST): a randomized, placebo-controlled study of metoprolol in the prevention of vasovagal syncope.

Authors:  Robert Sheldon; Stuart Connolly; Sarah Rose; Thomas Klingenheben; Andrew Krahn; Carlos Morillo; Mario Talajic; Teresa Ku; Fetnat Fouad-Tarazi; Debbie Ritchie; Mary-Lou Koshman
Journal:  Circulation       Date:  2006-02-27       Impact factor: 29.690

5.  Effect of etilefrine in preventing syncopal recurrence in patients with vasovagal syncope: a double-blind, randomized, placebo-controlled trial. The Vasovagal Syncope International Study.

Authors:  A Raviele; M Brignole; R Sutton; P Alboni; P Giani; C Menozzi; A Moya
Journal:  Circulation       Date:  1999-03-23       Impact factor: 29.690

6.  Dual-chamber pacing in the treatment of neurally mediated tilt-positive cardioinhibitory syncope : pacemaker versus no therapy: a multicenter randomized study. The Vasovagal Syncope International Study (VASIS) Investigators.

Authors:  R Sutton; M Brignole; C Menozzi; A Raviele; P Alboni; P Giani; A Moya
Journal:  Circulation       Date:  2000-07-18       Impact factor: 29.690

7.  Midodrine: a role in the management of neurocardiogenic syncope.

Authors:  C R Ward; J C Gray; J J Gilroy; R A Kenny
Journal:  Heart       Date:  1998-01       Impact factor: 5.994

8.  A randomized, double-blind, placebo-controlled study of permanent cardiac pacing for the treatment of recurrent tilt-induced vasovagal syncope. The vasovagal syncope and pacing trial (SYNPACE).

Authors:  Antonio Raviele; Franco Giada; Carlo Menozzi; Giancarlo Speca; Serafino Orazi; Gianni Gasparini; Richard Sutton; Michele Brignole
Journal:  Eur Heart J       Date:  2004-10       Impact factor: 29.983

9.  Physical manoeuvres that reduce postural hypotension in autonomic failure.

Authors:  W Wieling; J J van Lieshout; A M van Leeuwen
Journal:  Clin Auton Res       Date:  1993-02       Impact factor: 4.435

10.  Pacemaker therapy in patients with neurally mediated syncope and documented asystole: Third International Study on Syncope of Uncertain Etiology (ISSUE-3): a randomized trial.

Authors:  Michele Brignole; Carlo Menozzi; Angel Moya; Dietrich Andresen; Jean Jacques Blanc; Andrew D Krahn; Wouter Wieling; Xulio Beiras; Jean Claude Deharo; Vitantonio Russo; Marco Tomaino; Richard Sutton
Journal:  Circulation       Date:  2012-05-07       Impact factor: 29.690

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  1 in total

1.  [Reflex syncope and syncope secondary to orthostatic hypotension].

Authors:  G Simonis; U Gerk; F Pabst; J Machetanz; S G Spitzer; S Schellong
Journal:  Internist (Berl)       Date:  2015-01       Impact factor: 0.743

  1 in total

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