Literature DB >> 2474167

The relation of elevation of cytosolic free calcium to activation of membrane conductance in rat parotid acinar cells.

P T Gray1.   

Abstract

The relation between elevation of cytosolic free calcium and activation of membrane conductance has been studied in single acinar cells of the rat parotid. Outward and inward currents are activated by calcium elevation and oscillate in phase with oscillations of cytosolic calcium. The outward current results from activation of a large unit-conductance Ca2+ and voltage-dependent K+ channel, whereas the inward current is most likely carried predominantly by Cl-. Both these conductances have been previously described in exocrine cells. Buffering calcium at resting levels eliminated current responses to muscarinic agonists, suggesting that calcium is the only significant second messenger involved in the short-term control of this conductance by acetylcholine.

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Year:  1989        PMID： 2474167     DOI： 10.1098/rspb.1989.0039

Source DB:  PubMed          Journal:  Proc R Soc Lond B Biol Sci        ISSN： 0950-1193


  7 in total

1.  Effects of Ca2+ removal and of tetraethylammonium on membrane currents induced by carbachol in isolated cells from the rat parotid gland.

Authors:  T Shigetomi; T Hayashi; M Ueda; T Kaneda; H Tokuno; A Takai; T Tomita
Journal:  Pflugers Arch       Date:  1991-10       Impact factor: 3.657

2.  Effects of ammonium chloride on membrane currents of acinar cells dispersed from the rat parotid gland.

Authors:  T Hayashi; T Shigetomi; M Ueda; T Kaneda; T Matsumoto; H Tokuno; T Tomita
Journal:  Pflugers Arch       Date:  1992-03       Impact factor: 3.657

3.  Regulation of membrane potential and fluid secretion by Ca2+-activated K+ channels in mouse submandibular glands.

Authors:  Victor G Romanenko; Tetsuji Nakamoto; Alaka Srivastava; Ted Begenisich; James E Melvin
Journal:  J Physiol       Date:  2007-03-22       Impact factor: 5.182

4.  The ACh-induced whole-cell currents in sheep parotid secretory cells. Do BK channels really carry the ACh-evoked whole-cell K+ current?

Authors:  T Hayashi; C Hirono; J A Young; D I Cook
Journal:  J Membr Biol       Date:  1995-03       Impact factor: 1.843

5.  Three distinct chloride channels control anion movements in rat parotid acinar cells.

Authors:  J Arreola; K Park; J E Melvin; T Begenisich
Journal:  J Physiol       Date:  1996-01-15       Impact factor: 5.182

6.  Release of intracellular calcium and modulation of membrane currents by caffeine in bull-frog sympathetic neurones.

Authors:  N V Marrion; P R Adams
Journal:  J Physiol       Date:  1992-01       Impact factor: 5.182

7.  The control of chloride conductance in rat parotid isolated acinar cells investigated by photorelease of caged compounds.

Authors:  A A Hassoni; P T Gray
Journal:  Pflugers Arch       Date:  1994-10       Impact factor: 3.657
  7 in total

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