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Literature DB >> 24741086

Cellular transcriptome analysis reveals differential expression of pro- and antiapoptosis genes by varicella-zoster virus-infected neurons and fibroblasts.

Amos Markus¹, Hiba Waldman Ben-Asher¹, Paul R Kinchington², Ronald S Goldstein³.

Abstract

Transcriptional changes following varicella-zoster virus (VZV) infection of cultured human neurons derived from embryonic stem cells were compared to those in VZV-infected human foreskin fibroblasts. Transcription of 340 neuronal genes significantly altered by VZV infection included 223 transcript changes unique to neurons. Strikingly, genes inhibiting apoptosis were upregulated in neurons, while proapoptotic gene transcription was increased in fibroblasts. These data are a basis for discovery of differences in virus-host interactions between these VZV targets.

Entities: Disease Species

Mesh：

Substances：
Biomarkers

Year: 2014 PMID： 24741086 PMCID： PMC4054417 DOI： 10.1128/JVI.00500-14

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

15 in total

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4. Varicella-Zoster virus ORF12 protein triggers phosphorylation of ERK1/2 and inhibits apoptosis.

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5. Varicella-zoster virus and herpes simplex virus 1 can infect and replicate in the same neurons whether co- or superinfected.

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8. Inhibition of Bim enhances replication of varicella-zoster virus and delays plaque formation in virus-infected cells.

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9. Microarray analysis of host cell gene transcription in response to varicella-zoster virus infection of human T cells and fibroblasts in vitro and SCIDhu skin xenografts in vivo.

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10. RNA-seq analysis of host and viral gene expression highlights interaction between varicella zoster virus and keratinocyte differentiation.

Authors: Meleri Jones; Inga R Dry; Dan Frampton; Manuraj Singh; Ravinder K Kanda; Michael B Yee; Paul Kellam; Michael Hollinshead; Paul R Kinchington; Edel A O'Toole; Judith Breuer
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8. In vitro system using human neurons demonstrates that varicella-zoster vaccine virus is impaired for reactivation, but not latency.

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