Literature DB >> 24739843

Triple composite tumor of stomach: a rare combination of alpha fetoprotein positive hepatoid adenocarcinoma, tubular adenocarcinoma and large cell neuroendocrine carcinoma.

Lipika Lipi, Ritesh Sachdev1, Dheeraj Gautam, Jasbir Singh, Ishani Mohapatra.   

Abstract

A 50-year-old male patient presented with pain abdomen of 6 months duration. Computed tomography scan revealed a large mass in the stomach occluding the lumen. Histopathology revealed a triple composite tumor comprising of tubular adenocarcinoma arising on a background of high-grade dysplasia, hepatoid adenocarcinoma (positive for Hep Par-1 and alpha fetoprotein) and large cell neuroendocrine carcinoma (positive for synaptophysin and chromogranin) with nodal metastasis.Triple composite tumors are distinctly rare with few reports in literature.

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Year:  2014        PMID: 24739843     DOI: 10.4103/0377-4929.130912

Source DB:  PubMed          Journal:  Indian J Pathol Microbiol        ISSN: 0377-4929            Impact factor:   0.740


  5 in total

1.  Clinicopathological Characteristics and Prognosis of Hepatoid Adenocarcinoma of the Stomach: Evaluation of a Pooled Case Series.

Authors:  Xiang-Yu Zeng; Yu-Ping Yin; Hua Xiao; Peng Zhang; Jun He; Wei-Zhen Liu; Jin-Bo Gao; Xiao-Ming Shuai; Guo-Bin Wang; Xiu-Li Wu; Kai-Xiong Tao
Journal:  Curr Med Sci       Date:  2018-12-07

2.  Rapidly progressed large cell neuroendocrine carcinoma of the stomach with an increased serum alpha fetoprotein level: a case report.

Authors:  Koji Takahashi; Takeshi Nihei; Yohei Aoki; Naoaki Konno; Miyuki Nakagawa; Akari Munakata; Ken Okawara; Haruo Ohtani; Hiroshi Kashimura
Journal:  Clin J Gastroenterol       Date:  2019-09-11

3.  Gastric Adenocarcinoma with Dual Differentiation toward Neuroendocrine and α-Fetoprotein-Producing Features: Report of 2 Cases.

Authors:  Shun Iida; Shinichi Ban; Keizo Kato; Shinji Endo; Ryota Matsuo; Kosuke Hirano; Takashi Okuyama; Yukinori Yamagata; Yoshihiko Ueda
Journal:  Case Rep Gastroenterol       Date:  2017-11-02

4.  Gastric adenocarcinoma is concurrent with metastatic neuroendocrine cancer treated with nivolumab and chemotherapy: A case report.

Authors:  Bing Yan; Meiqi Cui; Junhao You; Fang Li; Hui Liu
Journal:  Mol Clin Oncol       Date:  2018-10-05

Review 5.  Hepatoid Adenocarcinoma of the Stomach: Current Perspectives and New Developments.

Authors:  Ruolan Xia; Yuwen Zhou; Yuqing Wang; Jiaming Yuan; Xuelei Ma
Journal:  Front Oncol       Date:  2021-04-12       Impact factor: 6.244

  5 in total

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