Literature DB >> 2473952

Suppression of frequently recurring genital herpes: acyclovir v inosine pranobex.

A Mindel1, O Carney, C Sonnex, M Freris, G Patou, P Williams.   

Abstract

The suppressive action of acyclovir and inosine pranobex was compared in a randomised double blind controlled trial in patients with frequently recurring genital herpes. Fourteen patients received acyclovir and 17 inosine pranobex. Treatment continued for 12 weeks. The time to the first recurrence was significantly longer and the frequency of recurrences significantly less in the recipients of acyclovir. No important side effects were noted. It is concluded that acyclovir is the treatment of choice to suppress often recurring genital herpes.

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Year:  1989        PMID： 2473952      PMCID： PMC1194297          DOI： 10.1136/sti.65.2.103

Source DB:  PubMed          Journal:  Genitourin Med        ISSN： 0266-4348


  13 in total

1.  Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl) guanine.

Authors:  G B Elion; P A Furman; J A Fyfe; P de Miranda; L Beauchamp; H J Schaeffer
Journal:  Proc Natl Acad Sci U S A       Date:  1977-12       Impact factor: 11.205

2.  Oral acyclovir suppression of recurrent genital herpes: a double-blind, placebo-controlled, crossover study.

Authors:  A M Halsos; O P Salo; A Lassus; E A Tjøtta; T Hovi; B O Gabrielsen; A P Fiddian
Journal:  Acta Derm Venereol       Date:  1985       Impact factor: 4.437

3.  Antiviral activity of isoprinosine in vitro and in vivo.

Authors:  T W Chang; L Weinstein
Journal:  Am J Med Sci       Date:  1973-02       Impact factor: 2.378

4.  Prophylactic oral acyclovir in recurrent genital herpes.

Authors:  A Mindel; I V Weller; A Faherty; S Sutherland; D Hindley; A P Fiddian; M W Adler
Journal:  Lancet       Date:  1984-07-14       Impact factor: 79.321

5.  Inosiplex in recurrent herpes simplex infections.

Authors:  M Galli; A Lazzarin; M Moroni; C Zanussi
Journal:  Lancet       Date:  1982-08-07       Impact factor: 79.321

6.  Genital herpes: hype or hope?

Authors:  M W Alder; A Mindel
Journal:  Br Med J (Clin Res Ed)       Date:  1983-06-04

7.  Inhibition of herpes simplex virus-induced DNA polymerase activity and viral DNA replication by 9-(2-hydroxyethoxymethyl)guanine and its triphosphate.

Authors:  P A Furman; M H St Clair; J A Fyfe; J L Rideout; P M Keller; G B Elion
Journal:  J Virol       Date:  1979-10       Impact factor: 5.103

8.  Isoprinosine: an overview.

Authors:  L N Simon; A J Glasky
Journal:  Cancer Treat Rep       Date:  1978-11

9.  Acyclovir prophylaxis of recurrent genital herpes: randomised placebo controlled crossover study.

Authors:  G R Kinghorn; M Jeavons; M Rowland; I Abeywickreme; I G Barton; C W Potter; E A Hickmott
Journal:  Genitourin Med       Date:  1985-12

10.  Recurrent genital herpes: clinical and virological features in men and women.

Authors:  A Mindel; D M Coker; A Faherty; P Williams
Journal:  Genitourin Med       Date:  1988-04
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  4 in total

1.  Acyclovir vs isoprinosine (immunovir) for suppression of recurrent genital herpes simplex infection.

Authors:  G R Kinghorn; P D Woolley; R N Thin; J De Maubeuge; J M Foidart; R Engst
Journal:  Genitourin Med       Date:  1992-10

Review 2.  Aciclovir. A reappraisal of its antiviral activity, pharmacokinetic properties and therapeutic efficacy.

Authors:  A J Wagstaff; D Faulds; K L Goa
Journal:  Drugs       Date:  1994-01       Impact factor: 9.546

Review 3.  Inosine Pranobex: A Key Player in the Game Against a Wide Range of Viral Infections and Non-Infectious Diseases.

Authors:  Jiri Sliva; Chrysoula N Pantzartzi; Martin Votava
Journal:  Adv Ther       Date:  2019-06-05       Impact factor: 3.845

Review 4.  Inosine Pranobex Deserves Attention as a Potential Immunomodulator to Achieve Early Alteration of the COVID-19 Disease Course.

Authors:  Jiří Beran; Marián Špajdel; Jiří Slíva
Journal:  Viruses       Date:  2021-11-09       Impact factor: 5.048
  4 in total

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