Literature DB >> 2473920

Charybdotoxin blocks both Ca-activated K channels and Ca-independent voltage-gated K channels in rat brain synaptosomes.

M J Schneider1, R S Rogowski, B K Krueger, M P Blaustein.   

Abstract

Charybdotoxin (ChTX), a 4.3 kDa polypeptide toxin from the venom of the scorpion Leiurus quinquestriatus, blocks both a Ca-activated K channel (IC50 approximately 15 nM) and a Ca-independent voltage-gated K channel (IC50 approximately 40 nM) in rat brain synaptosomes. These results indicate that in this preparation ChTX is not specific for the Ca-activated K channel and suggest that there may be structural homology among the toxin-binding sites on various types of K channels.

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Year:  1989        PMID： 2473920     DOI： 10.1016/0014-5793(89)80771-9

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  11 in total

1.  Dual and opposing roles of presynaptic Ca2+ influx for spontaneous GABA release from rat medial preoptic nerve terminals.

Authors:  Michael Druzin; David Haage; Evgenya Malinina; Staffan Johansson
Journal:  J Physiol       Date:  2002-07-01       Impact factor: 5.182

2.  Design, synthesis, and functional expression of a gene for charybdotoxin, a peptide blocker of K+ channels.

Authors:  C S Park; S F Hausdorff; C Miller
Journal:  Proc Natl Acad Sci U S A       Date:  1991-03-15       Impact factor: 11.205

Review 3.  Use of toxins to study potassium channels.

Authors:  M L Garcia; A Galvez; M Garcia-Calvo; V F King; J Vazquez; G J Kaczorowski
Journal:  J Bioenerg Biomembr       Date:  1991-08       Impact factor: 2.945

4.  Scorpion toxin block of the early K+ current (IKf) in rat dorsal root ganglion neurones.

Authors:  D R Matteson; M P Blaustein
Journal:  J Physiol       Date:  1997-09-01       Impact factor: 5.182

Review 5.  Big Potassium (BK) ion channels in biology, disease and possible targets for cancer immunotherapy.

Authors:  Lisheng Ge; Neil T Hoa; Zechariah Wilson; Gabriel Arismendi-Morillo; Xiao-Tang Kong; Rajeev B Tajhya; Christine Beeton; Martin R Jadus
Journal:  Int Immunopharmacol       Date:  2014-07-12       Impact factor: 4.932

6.  Single-channel properties of BK-type calcium-activated potassium channels at a cholinergic presynaptic nerve terminal.

Authors:  X P Sun; L C Schlichter; E F Stanley
Journal:  J Physiol       Date:  1999-08-01       Impact factor: 5.182

Review 7.  Modulation of BK Channel Function by Auxiliary Beta and Gamma Subunits.

Authors:  Q Li; J Yan
Journal:  Int Rev Neurobiol       Date:  2016-04-08       Impact factor: 3.230

8.  Modulation of acetylcholine release at mouse neuromuscular junctions by interaction of three homologous scorpion toxins with K+ channels.

Authors:  H Vatanpour; A L Harvey
Journal:  Br J Pharmacol       Date:  1995-04       Impact factor: 8.739

9.  Tityustoxin K alpha blocks voltage-gated noninactivating K+ channels and unblocks inactivating K+ channels blocked by alpha-dendrotoxin in synaptosomes.

Authors:  R S Rogowski; B K Krueger; J H Collins; M P Blaustein
Journal:  Proc Natl Acad Sci U S A       Date:  1994-02-15       Impact factor: 11.205

10.  Fast, persistent, Ca(2+)-dependent K+ current controls graded electrical activity in crayfish muscle.

Authors:  A Araque; W Buño
Journal:  Pflugers Arch       Date:  1995-08       Impact factor: 3.657
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