Literature DB >> 2473859

Autoimmune response to the Ro/SSA particle is directed to the human antigen.

M Reichlin1, M Rader, J B Harley.   

Abstract

Autoantibodies to defined cellular antigens in systemic lupus erythematosus (SLE) are usually directed to conserved epitopes on ubiquitous macromolecules including histone, Sm + nRNP (URNP particles), DNA, and La(SSB). We report here that the autoimmune response to the Ro(SSA) RNA protein particle is directed to epitopes on the human antigen which are not conserved in evolution. Ro(SSA) from bovine, rat, and mouse Ro(SSA) particles cross-react with human autoantibodies less effectively than does human Ro(SSA), and antigenically active Ro(SSA) is not detectable in chicken thymus extracts with the assays employed. These data suggest a special role for the Ro(SSA) antigen in the initiation and/or perpetuation of the anti-Ro(SSA) response in autoimmune disease.

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Year:  1989        PMID： 2473859      PMCID： PMC1541897     

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  26 in total

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Journal:  Science       Date:  1981-01-23       Impact factor: 47.728

5.  Heterogeneity of precipitating antibodies in polymyositis and dermatomyositis. Characterization of the Jo-1 antibody system.

Authors:  M Nishikai; M Reichlin
Journal:  Arthritis Rheum       Date:  1980-08

6.  Rabbit antibodies induced by calf thymus histone-serum albumin complexes.

Authors:  A L Sandberg; M Liss; B D Stollar
Journal:  J Immunol       Date:  1967-06       Impact factor: 5.422

7.  Restrictions in the response to autologous thyroglobulin in the human.

Authors:  L Nye; L C Pontes de Carvalho; I M Roitt
Journal:  Clin Exp Immunol       Date:  1980-08       Impact factor: 4.330

8.  Characterization of a high molecular weight acidic nuclear protein recognized by autoantibodies in sera from patients with polymyositis-scleroderma overlap.

Authors:  T Mimori; M Akizuki; H Yamagata; S Inada; S Yoshida; M Homma
Journal:  J Clin Invest       Date:  1981-09       Impact factor: 14.808

9.  Sequence of U1 RNA from Drosophila melanogaster: implications for U1 secondary structure and possible involvement in splicing.

Authors:  S M Mount; J A Steitz
Journal:  Nucleic Acids Res       Date:  1981-12-11       Impact factor: 16.971

10.  Ro small cytoplasmic ribonucleoproteins are a subclass of La ribonucleoproteins: further characterization of the Ro and La small ribonucleoproteins from uninfected mammalian cells.

Authors:  J P Hendrick; S L Wolin; J Rinke; M R Lerner; J A Steitz
Journal:  Mol Cell Biol       Date:  1981-12       Impact factor: 4.272
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  18 in total

1.  Key residues revealed in a major conformational epitope of the U1-70K protein.

Authors:  E Welin Henriksson; M Wahren-Herlenius; I Lundberg; E Mellquist; I Pettersson
Journal:  Proc Natl Acad Sci U S A       Date:  1999-12-07       Impact factor: 11.205

2.  Antibodies to extractable nuclear antigens. Has technological drift affected clinical interpretation?

Authors:  R J Lock; D J Unsworth
Journal:  J Clin Pathol       Date:  2001-03       Impact factor: 3.411

Review 3.  B-cell epitopes of La and Ro autoantigens.

Authors:  S Whittingham
Journal:  Mol Biol Rep       Date:  1992-06       Impact factor: 2.316

Review 4.  Autoantibodies against small cytoplasmic ribonucleoproteins: the anti-Ro/SS-A and anti-La/SS-B autoimmune response. A review of autoantibody detection, autoantigen composition, autoantibody-disease associations and possible etiologic mechanisms.

Authors:  J F Meilof
Journal:  Rheumatol Int       Date:  1992       Impact factor: 2.631

Review 5.  Antinuclear antibody determination methods.

Authors:  D G Williams; P J Charles; M Field; S M Chua; R N Maini
Journal:  Clin Rheumatol       Date:  1990-03       Impact factor: 2.980

Review 6.  Systemic lupus erythematosus: RNA-protein autoantigens, models of disease heterogeneity, and theories of etiology.

Authors:  J B Harley; R H Scofield
Journal:  J Clin Immunol       Date:  1991-11       Impact factor: 8.317

7.  Identification of a human-specific epitope in a conserved region of the La/SS-B autoantigen.

Authors:  Y M Weng; J McNeilage; F Topfer; J McCluskey; T Gordon
Journal:  J Clin Invest       Date:  1993-08       Impact factor: 14.808

8.  Calreticulin synthetic peptide analogues: anti-peptide antibodies in autoimmune rheumatic diseases.

Authors:  J G Routsias; A G Tzioufas; M Sakarellos-Daitsiotis; C Sakarellos; H M Moutsopoulos
Journal:  Clin Exp Immunol       Date:  1993-03       Impact factor: 4.330

9.  Autoantigenicity of Ro/SSA antigen is related to a nucleocapsid protein of vesicular stomatitis virus.

Authors:  R H Scofield; J B Harley
Journal:  Proc Natl Acad Sci U S A       Date:  1991-04-15       Impact factor: 11.205

10.  La/SSB ribonucleoprotein levels increased in transformed cells.

Authors:  R P Rother; P S Thomas
Journal:  Clin Exp Immunol       Date:  1991-03       Impact factor: 4.330
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