Literature DB >> 24737572

TGF-beta signaling-dependent alleviation of dextran sulfate sodium-induced colitis by mesenchymal stem cell transplantation.

Chong Wang1, Jing Chen, Ling Sun, Yanfang Liu.   

Abstract

Alleviation of dextran sulfate sodium (DSS)-induced colitis was shown after by transplantation of bone marrow derived cells in mice. Nevertheless, the underlying mechanism remains elusive. In the present study, we transplanted primary mouse mesenchymal stem cells (MSC) into isogeneic mice with DSS-induced colitis. We found that MSC transplantation significantly alleviated the DSS-induced colitis. Inhibition of transforming growth factor beta (TGF-beta) signaling abrogated the therapeutic effect of MSC transplantation on DSS-colitis, suggesting a TGF-beta signaling-dependent manner. Moreover, MSC transplantation seemed to induce M2 macrophage polarization, which appeared to be the major source of TGF-beta in this model. Our data thus demonstrate that MSC transplantation may activate TGF-beta signaling pathways to promote the recovery of DSS-colitis.

Entities:  

Mesh：

Substances：

Year:  2014        PMID： 24737572     DOI： 10.1007/s11033-014-3364-6

Source DB:  PubMed          Journal:  Mol Biol Rep        ISSN： 0301-4851            Impact factor:   2.316


  29 in total

1.  A simple index for assessment of disease activity in patients with ulcerative colitis.

Authors:  I Rutegård; L Ahsgren; R Stenling; T Nilsson
Journal:  Hepatogastroenterology       Date:  1990-12

2.  Treatment of colitis with a commensal gut bacterium engineered to secrete human TGF-β1 under the control of dietary xylan 1.

Authors:  Zaed Z R Hamady; Nigel Scott; Mark D Farrar; Meenu Wadhwa; Paula Dilger; Terence R Whitehead; Robin Thorpe; Keith T Holland; J Peter A Lodge; Simon R Carding
Journal:  Inflamm Bowel Dis       Date:  2010-12-17       Impact factor: 5.325

Review 3.  Stem cell plasticity.

Authors:  Catherine Verfaillie
Journal:  Hematology       Date:  2005       Impact factor: 2.269

4.  T regulatory cell suppression of colitis: the role of TGF-beta.

Authors:  R Duchmann; M Zeitz
Journal:  Gut       Date:  2006-05       Impact factor: 23.059

5.  Isolation and culture of mouse intestinal cells.

Authors:  Charles Frederick Campbell
Journal:  Methods Mol Biol       Date:  2010

6.  Identification of novel inhibitors of the transforming growth factor beta1 (TGF-beta1) type 1 receptor (ALK5).

Authors:  James F Callahan; Joelle L Burgess; James A Fornwald; Laramie M Gaster; John D Harling; Frank P Harrington; Jag Heer; Chet Kwon; Ruth Lehr; A Mathur; Barbara A Olson; Joseph Weinstock; Nicholas J Laping
Journal:  J Med Chem       Date:  2002-02-28       Impact factor: 7.446

7.  TGF-beta1 production in inflammatory bowel disease: differing production patterns in Crohn's disease and ulcerative colitis.

Authors:  B Del Zotto; G Mumolo; A M Pronio; C Montesani; R Tersigni; M Boirivant
Journal:  Clin Exp Immunol       Date:  2003-10       Impact factor: 4.330

8.  Chronic experimental colitis induced by dextran sulphate sodium (DSS) is characterized by Th1 and Th2 cytokines.

Authors:  L A Dieleman; M J Palmen; H Akol; E Bloemena; A S Peña; S G Meuwissen; E P Van Rees
Journal:  Clin Exp Immunol       Date:  1998-12       Impact factor: 4.330

9.  The transdifferentiation of bone-marrow-derived cells in colonic mucosal regeneration after dextran-sulfate-sodium-induced colitis in mice.

Authors:  Yujiro Hayashi; Shingo Tsuji; Masahiko Tsujii; Tsutomu Nishida; Shuji Ishii; Tohru Nakamura; Hiroshi Eguchi; Sunao Kawano
Journal:  Pharmacology       Date:  2007-06-20       Impact factor: 2.547

10.  SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7.

Authors:  Gareth J Inman; Francisco J Nicolás; James F Callahan; John D Harling; Laramie M Gaster; Alastair D Reith; Nicholas J Laping; Caroline S Hill
Journal:  Mol Pharmacol       Date:  2002-07       Impact factor: 4.436
View more
  14 in total

1.  Stem cells for murine interstitial cells of cajal suppress cellular immunity and colitis via prostaglandin E2 secretion.

Authors:  Maneesh Dave; Yujiro Hayashi; Gabriella B Gajdos; Thomas C Smyrk; Phyllis A Svingen; Sergiy M Kvasha; Andrea Lorincz; Haidong Dong; William A Faubion; Tamas Ordog
Journal:  Gastroenterology       Date:  2015-01-28       Impact factor: 22.682

2.  Ginsenoside Rh2 alleviates dextran sulfate sodium-induced colitis via augmenting TGFβ signaling.

Authors:  Hua Ye; Qiong Wu; Yuzhen Zhu; Cancan Guo; Xuebao Zheng
Journal:  Mol Biol Rep       Date:  2014-06-04       Impact factor: 2.316

3.  Splenic macrophage phagocytosis of intravenously infused mesenchymal stromal cells attenuates tumor localization.

Authors:  Suheyla Hasgur; Laura Desbourdes; Theresa Relation; Kathleen M Overholt; Joseph R Stanek; Adam J Guess; Minjun Yu; Pratik Patel; Linda Roback; Massimo Dominici; Satoru Otsuru; Edwin M Horwitz
Journal:  Cytotherapy       Date:  2021-03-26       Impact factor: 5.414

4.  Human cord blood-derived platelet lysate enhances the therapeutic activity of adipose-derived mesenchymal stromal cells isolated from Crohn's disease patients in a mouse model of colitis.

Authors:  Dorian Forte; Marilena Ciciarello; Maria Chiara Valerii; Luigia De Fazio; Elena Cavazza; Rosaria Giordano; Valentina Parazzi; Lorenza Lazzari; Silvio Laureti; Fernando Rizzello; Michele Cavo; Antonio Curti; Roberto M Lemoli; Enzo Spisni; Lucia Catani
Journal:  Stem Cell Res Ther       Date:  2015-09-09       Impact factor: 6.832

5.  Pharmacological Inhibition of Gal-3 in Mesenchymal Stem Cells Enhances Their Capacity to Promote Alternative Activation of Macrophages in Dextran Sulphate Sodium-Induced Colitis.

Authors:  Bojana Simovic Markovic; Aleksandar Nikolic; Marina Gazdic; Jasmin Nurkovic; Irena Djordjevic; Nebojsa Arsenijevic; Miodrag Stojkovic; Miodrag L Lukic; Vladislav Volarevic
Journal:  Stem Cells Int       Date:  2016-01-04       Impact factor: 5.443

6.  The neuroprotective effects of human bone marrow mesenchymal stem cells are dose-dependent in TNBS colitis.

Authors:  Ainsley M Robinson; Ahmed A Rahman; Sarah Miller; Rhian Stavely; Samy Sakkal; Kulmira Nurgali
Journal:  Stem Cell Res Ther       Date:  2017-04-18       Impact factor: 6.832

Review 7.  Genetic contribution to mesenchymal stem cell dysfunction in systemic lupus erythematosus.

Authors:  Yantong Zhu; Xuebing Feng
Journal:  Stem Cell Res Ther       Date:  2018-05-24       Impact factor: 6.832

Review 8.  Mesenchymal Stem Cell-Macrophage Crosstalk and Maintenance of Inflammatory Microenvironment Homeostasis.

Authors:  Di Lu; Yan Xu; Qiuli Liu; Qi Zhang
Journal:  Front Cell Dev Biol       Date:  2021-06-25

9.  Human adult stem cells derived from adipose tissue and bone marrow attenuate enteric neuropathy in the guinea-pig model of acute colitis.

Authors:  Rhian Stavely; Ainsley M Robinson; Sarah Miller; Richard Boyd; Samy Sakkal; Kulmira Nurgali
Journal:  Stem Cell Res Ther       Date:  2015-12-10       Impact factor: 6.832

Review 10.  Can a Conversation Between Mesenchymal Stromal Cells and Macrophages Solve the Crisis in the Inflamed Intestine?

Authors:  Laura Hidalgo-Garcia; Julio Galvez; M Elena Rodriguez-Cabezas; Per O Anderson
Journal:  Front Pharmacol       Date:  2018-03-06       Impact factor: 5.810
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.