Huai-Ren Chang1, Jen-Che Hsieh, Bang-Gee Hsu, Ling-Yi Wang, Michael Yu-Chih Chen, Ji-Hung Wang. 1. Divisions of Cardiology (H-RC, J-CH, MYC, J-HW) and Nephrology (B-GH), Department of Internal Medicine, Buddhist Tzu Chi General Hospital, Hualien, Taiwan; Institute of Medical Sciences (H-RC, MYC), Tzu Chi University, Hualien, Taiwan; School of Medicine (B-GH, J-HW), Tzu Chi University, Hualien, Taiwan; and Institute of Epidemiology & Preventive Medicine (L-YW), College of Public Health, National Taiwan University, Taipei, Taiwan.
Abstract
BACKGROUND: It has been shown that metabolic syndrome is associated with lower levels of plasma N-terminal pro-B-type natriuretic peptide (Nt-proBNP) in the general population. However, there is no study about the association between Nt-proBNP and metabolic syndrome in hypertensive patients. AIM: : To elucidate the relationship between Nt-proBNP and components of metabolic syndrome in hypertensive patients. METHODS: Fasting blood samples were obtained from 74 hypertensive patients in our institution. Plasma levels of Nt-proBNP and other biochemical data were measured. Metabolic syndrome and its components were defined using diagnostic criteria from the International Diabetes Federation. RESULTS: Forty-four hypertensive patients met the criteria for metabolic syndrome. We found that plasma Nt-proBNP levels were lower in hypertensive patients with metabolic syndrome attributable to inverse relationships between Nt-proBNP and albumin, triglyceride, insulin, homeostasis model assessment of insulin resistance (HOMA-IR) and pancreatic β-cell function (HOMA-β). We further performed a multivariable linear regression analysis. The result showed that HOMA-IR is the independent predictor of plasma Nt-proBNP levels in hypertensive patients. CONCLUSIONS: Plasma Nt-proBNP levels are inversely associated with metabolic syndrome in hypertensive patients. HOMA-IR is the independent predictor of Nt-proBNP in hypertensive patients.
BACKGROUND: It has been shown that metabolic syndrome is associated with lower levels of plasma N-terminal pro-B-type natriuretic peptide (Nt-proBNP) in the general population. However, there is no study about the association between Nt-proBNP and metabolic syndrome in hypertensivepatients. AIM: : To elucidate the relationship between Nt-proBNP and components of metabolic syndrome in hypertensivepatients. METHODS: Fasting blood samples were obtained from 74 hypertensivepatients in our institution. Plasma levels of Nt-proBNP and other biochemical data were measured. Metabolic syndrome and its components were defined using diagnostic criteria from the International Diabetes Federation. RESULTS: Forty-four hypertensivepatients met the criteria for metabolic syndrome. We found that plasma Nt-proBNP levels were lower in hypertensivepatients with metabolic syndrome attributable to inverse relationships between Nt-proBNP and albumin, triglyceride, insulin, homeostasis model assessment of insulin resistance (HOMA-IR) and pancreatic β-cell function (HOMA-β). We further performed a multivariable linear regression analysis. The result showed that HOMA-IR is the independent predictor of plasma Nt-proBNP levels in hypertensivepatients. CONCLUSIONS: Plasma Nt-proBNP levels are inversely associated with metabolic syndrome in hypertensivepatients. HOMA-IR is the independent predictor of Nt-proBNP in hypertensivepatients.
Authors: Otto A Sanchez; Mariana Lazo-Elizondo; Irfan Zeb; Russell P Tracy; Ryan Bradley; Daniel A Duprez; Hossein Bahrami; Carmen A Peralta; Lori B Daniels; João A Lima; Alan Maisel; David R Jacobs; Mathew J Budoff Journal: Metabolism Date: 2016-02-27 Impact factor: 8.694
Authors: Paweł Krzesiński; Wiesław Piechota; Katarzyna Piotrowicz; Grzegorz Gielerak; Agnieszka Woźniak-Kosek Journal: Cardiol Res Pract Date: 2019-12-18 Impact factor: 1.866