Literature DB >> 2473642

Effects of antihistamines on isolated human lung mast cells, basophil leucocytes and erythrocytes.

H Y Lau1, F L Pearce.   

Abstract

Low concentrations of H1- and H2-receptor directed compounds inhibited the immunologic secretion of histamine from human lung mast cells and basophil leucocytes and protected human erythrocytes from hypotonic lysis. Higher concentrations induced a release of the amine from the histaminocytes. These results are discussed in terms of the possible membrane effects of the test compounds.

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Year:  1989        PMID： 2473642     DOI： 10.1007/bf02222205

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  6 in total

1.  The anti-anaphylactic and histamine-releasing properties of the antihistamines. Their effect on the mast cells.

Authors:  I MOTA; W da SILVA
Journal:  Br J Pharmacol Chemother       Date:  1960-09

2.  Human mast cells recovered by bronchoalveolar lavage: their morphology, histamine release and the effects of sodium cromoglycate.

Authors:  K C Flint; K B Leung; F L Pearce; B N Hudspith; J Brostoff; N M Johnson
Journal:  Clin Sci (Lond)       Date:  1985-04       Impact factor: 6.124

Review 3.  The membrane actions of anesthetics and tranquilizers.

Authors:  P Seeman
Journal:  Pharmacol Rev       Date:  1972-12       Impact factor: 25.468

4.  Effect of chlorpromazine, mepyramine, prenylamine and reserpine of 5-hydroxytryptamine content and fine structure of rat peritoneal mast cells incubated in vitro.

Authors:  S E Jansson
Journal:  Acta Physiol Scand       Date:  1970-03

5.  On the mechanism of chlorpromazine-induced histamine release from rat mast cells.

Authors:  M Frisk-Holmberg
Journal:  Acta Physiol Scand       Date:  1971-11

6.  Some studies on human pulmonary mast cells obtained by bronchoalveolar lavage and by enzymic dissociation of whole lung tissue.

Authors:  F L Pearce; K C Flint; K B Leung; B N Hudspith; K Seager; M D Hammond; J Brostoff; D Geraint-James; N M Johnson
Journal:  Int Arch Allergy Appl Immunol       Date:  1987
  6 in total
  5 in total

1.  Plasma histamine levels in polytraumatized patients.

Authors:  M Ennis; M Sangmeister; E Neugebauer; H Knaepler; M Fischer; W Dietz; W Lorenz
Journal:  Agents Actions       Date:  1990-04

2.  Modulation of IgE-mediated histamine release from human leukocytes by a new class of histamine H2-agonists.

Authors:  J Kleine-Tebbe; A Buschauer; A Friese; W Schunack; G Kunkel
Journal:  Agents Actions       Date:  1992-03

3.  The influence of H1-, H2- and H3-receptors on the spontaneous and ConA induced histamine release from human adenoidal mast cells.

Authors:  S Bent; U Fehling; U Braam; W Schunack; W Schmutzler
Journal:  Agents Actions       Date:  1991-05

4.  Time-course of the histamine release from human peripheral blood monocytes and the influence of ketotifen and disodium cromoglycate (DSCG).

Authors:  G Zwadlo-Klarwasser; U Braam; C Jungbluth; W Schmutzler
Journal:  Inflamm Res       Date:  1995-04       Impact factor: 4.575

5.  Inhibition of mediator release in RBL-2H3 cells by some H1-antagonist derived anti-allergic drugs: relation to lipophilicity and membrane effects.

Authors:  M J Fischer; J J Paulussen; D A Horbach; E P Roelofsen; J C van Miltenburg; N J de Mol; L H Janssen
Journal:  Inflamm Res       Date:  1995-02       Impact factor: 4.575
  5 in total

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