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Literature DB >> 2473628

Effect of amiloride on arachidonic acid and histamine release from rat mast cells.

Abstract

The effect of a putative Na+/H+ exchange inhibition on histamine and [14C]arachidonic acid ([14C]AA) release has been examined in rat peritoneal mast cells, using either addition of amiloride or removal of extracellular Na+. The cells were stimulated by non-immunological agents, i.e. calcium ionophore A23187, nerve growth factor (NGF), thapsigargin and compound 48/80. On the basis of the results obtained, a possible role for Na+/H+ exchange in rat mast cell secretion is discussed.

Entities: Chemical Gene Species

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Year: 1989 PMID： 2473628 DOI： 10.1007/bf02222192

Source DB: PubMed Journal: Agents Actions ISSN： 0065-4299

11 in total

Review 1. The role of phospholipid-derived mediators including arachidonic acid, its metabolites, and inositoltrisphosphate and of intracellular Ca2+ in glucose-induced insulin secretion by pancreatic islets.

Authors: J Turk; B A Wolf; M L McDaniel
Journal: Prog Lipid Res Date: 1987 Impact factor: 16.195

2. Inhibition by amiloride and by Na+-depletion of A23187-stimulated arachidonic acid and histamine release from rat mast cells.

Authors: H Linnebjerg; H S Hansen; B Jensen
Journal: FEBS Lett Date: 1988-11-21 Impact factor: 4.124

8. A simplified method for measuring basophil histamine release and blocking antibodies in hay fever patients. Basophil histamine content and cell preservation.

Authors: P S Skov; S Norn
Journal: Acta Allergol Date: 1977-06

9. Synergism between thapsigargin and the phorbol ester 12-O-tetradecanoylphorbol 13-acetate on the release of [14C]arachidonic acid and histamine from rat peritoneal mast cells.

Authors: S Jacobsen; H S Hansen; B Jensen
Journal: Biochem Pharmacol Date: 1987-03-01 Impact factor: 5.858

10. cis-Unsaturated fatty acids induce the fusion of chromaffin granules aggregated by synexin.

Authors: C E Creutz
Journal: J Cell Biol Date: 1981-10 Impact factor: 10.539

1 in total

1. Dual regulation of the Na+/H(+)-exchange in rat peritoneal mast cells: role of protein kinase C and calcium on pHi regulation and histamine release.

Authors: U G Friis; T Johansen
Journal: Br J Pharmacol Date: 1996-07 Impact factor: 8.739

1 in total

Effect of amiloride on arachidonic acid and histamine release from rat mast cells.

Review 1. The role of phospholipid-derived mediators including arachidonic acid, its metabolites, and inositoltrisphosphate and of intracellular Ca2+ in glucose-induced insulin secretion by pancreatic islets.

2. Inhibition by amiloride and by Na+-depletion of A23187-stimulated arachidonic acid and histamine release from rat mast cells.

Review 3. Mechanism of signal transduction in mast cells and basophils: studies with RBL-2H3 cells.

Review 4. Na+/H+ exchange as a modulator of platelet activation.

5. Interaction between nerve growth factor and lysophosphatidylserine on rat peritoneal mast cells.

6. Thapsigargine and thapsigargicine, two new histamine liberators from Thapsia garganica L.

Review 7. Activation of basophils and mast cells for mediator release.

8. A simplified method for measuring basophil histamine release and blocking antibodies in hay fever patients. Basophil histamine content and cell preservation.

9. Synergism between thapsigargin and the phorbol ester 12-O-tetradecanoylphorbol 13-acetate on the release of [14C]arachidonic acid and histamine from rat peritoneal mast cells.

10. cis-Unsaturated fatty acids induce the fusion of chromaffin granules aggregated by synexin.

1. Dual regulation of the Na+/H(+)-exchange in rat peritoneal mast cells: role of protein kinase C and calcium on pHi regulation and histamine release.