| Literature DB >> 2473608 |
G Siegel1, F Schnalke, G Stock, J Grote.
Abstract
In arterial smooth muscle with normal tone or predepolarized and precontracted by noradrenaline, prostacyclin (10(-9) to 10(-6) M) effects a dose-dependent hyperpolarization and relaxation. The hyperpolarization is due to K+ channel opening. In hypoxic vasodilatation, which is likewise induced by membrane hyperpolarization, a share of 20% falls to prostacyclin and 80% to an endothelium derived hyperpolarizing factor.Entities:
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Year: 1989 PMID： 2473608
Source DB: PubMed Journal: Adv Prostaglandin Thromboxane Leukot Res ISSN： 0732-8141