Literature DB >> 24735600

Associations of epithelial sodium channel genes with blood pressure changes and hypertension incidence: the GenSalt study.

Xueli Yang1, Jiang He2, Dongfeng Gu3, James E Hixson4, Jianfeng Huang5, Dabeeru C Rao6, Lawrence C Shimmin4, Jichun Chen5, Treva K Rice6, Jianxin Li5, Karen Schwander6, Tanika N Kelly7.   

Abstract

BACKGROUND: We examined the associations of epithelial sodium channel (ENaC) genes with blood pressure (BP) changes and hypertension incidence in a longitudinal family study.
METHODS: A total of 2,755 Han Chinese participants of the Genetic Epidemiology Network of Salt Sensitivity (GenSalt) baseline examination were eligible for this study. The associations of 43 tag single nucleotide polymorphisms (SNPs) in ENaC genes with BP changes and hypertension incidence were assessed using mixed models to account for the correlations of repeated measures among individuals and within families. A genotype by time interaction term was used to model differences in longitudinal BP change according to genotype over time. Gene-based analyses were conducted using the truncated product method. The Bonferroni method was used to adjust for multiple testing in all analyses.
RESULTS: During an average of 7.4 years follow-up, systolic BP (SBP) and diastolic BP (DBP) increased, and approximately 33% of participants developed hypertension. SCNN1A SNP rs11064153 and SCNN1G SNP rs4401050 were significantly associated with longitudinal changes in SBP after adjustment for multiple testing (P interaction = 5.8×10(-4) and 0.001, respectively). Similar but nonsignificant trends were observed for the associations between both rs11064153 and rs4401050 and DBP changes (P interaction = 0.024 and 0.005, respectively) and between rs11604153 and hypertension incidence (P = 0.02). Gene-based analyses also supported the overall association of SCNN1G with longitudinal changes in SBP (P = 2.0×10(-4)).
CONCLUSIONS: Our findings indicated that SCNN1A and SCNN1G may contribute to BP changes over time in the Han Chinese population. Replication of these findings is warranted. © American Journal of Hypertension, Ltd 2014. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Entities:  

Keywords:  blood pressure; blood pressure changes; epithelial sodium channel (ENaC); hypertension; single nucleotide polymorphisms.

Mesh：

Substances：

Year:  2014        PMID： 24735600      PMCID： PMC4263940          DOI： 10.1093/ajh/hpu060

Source DB:  PubMed          Journal:  Am J Hypertens        ISSN： 0895-7061            Impact factor:   2.689


  30 in total

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Review 2.  Between candidate genes and whole genomes: time for alternative approaches in blood pressure genetics.

Authors:  Jacob Basson; Jeannette Simino; D C Rao
Journal:  Curr Hypertens Rep       Date:  2012-02       Impact factor: 5.369

3.  Selective genotyping reveals association between the epithelial sodium channel gamma-subunit and systolic blood pressure.

Authors:  Cara J Büsst; Katrina J Scurrah; Justine A Ellis; Stephen B Harrap
Journal:  Hypertension       Date:  2007-08-13       Impact factor: 10.190

4.  [Relationship between four single nucleotide polymorphisms of epithelial sodium channel alpha subunit gene and essential hypertension of Kazakhs in Xinjiang].

Authors:  Hong Xu; Nan-fang Li; Jing Hong; Li Zhang; Ling Zhou; Tao Li; Wei-jin Ou Yang; Qiu-yan Cheng
Journal:  Zhongguo Yi Xue Ke Xue Yuan Xue Bao       Date:  2009-12

5.  Interactions of genetic variants with physical activity are associated with blood pressure in Chinese: the GenSalt study.

Authors:  May E Montasser; Donfeng Gu; Jing Chen; Lawrence C Shimmin; Charles Gu; Tanika N Kelly; Cashell E Jaquish; Treva Rice; Dabeeru C Rao; Jie Cao; Jichun Chen; De-Pei Liu; Paul K Whelton; Jiang He; James E Hixson
Journal:  Am J Hypertens       Date:  2011-06-09       Impact factor: 2.689

Review 6.  Genome-wide association studies: contribution of genomics to understanding blood pressure and essential hypertension.

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Journal:  Curr Hypertens Rep       Date:  2010-02       Impact factor: 5.369

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8.  A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010.

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9.  Liddle's syndrome caused by a novel missense mutation (P617L) of the epithelial sodium channel beta subunit.

Authors:  Ermanno Rossi; Enrico Farnetti; Anne Debonneville; Davide Nicoli; Chiara Grasselli; Giuseppe Regolisti; Aurelio Negro; Franco Perazzoli; Bruno Casali; Franco Mantero; Olivier Staub
Journal:  J Hypertens       Date:  2008-05       Impact factor: 4.844

Review 10.  Use of blood pressure lowering drugs in the prevention of cardiovascular disease: meta-analysis of 147 randomised trials in the context of expectations from prospective epidemiological studies.

Authors:  M R Law; J K Morris; N J Wald
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  8 in total

1.  Associations of Variants in the CACNA1A and CACNA1C Genes With Longitudinal Blood Pressure Changes and Hypertension Incidence: The GenSalt Study.

Authors:  Zunsong Hu; Fangchao Liu; Mengting Li; Jiang He; Jianfeng Huang; Dabeeru C Rao; James E Hixson; Charles Gu; Tanika N Kelly; Shufeng Chen; Dongfeng Gu; Xueli Yang
Journal:  Am J Hypertens       Date:  2016-11-01       Impact factor: 2.689

2.  Human epithelial Na+ channel missense variants identified in the GenSalt study alter channel activity.

Authors:  Evan C Ray; Jingxin Chen; Tanika N Kelly; Jiang He; L Lee Hamm; Dongfeng Gu; Lawrence C Shimmin; James E Hixson; Dabeeru C Rao; Shaohu Sheng; Thomas R Kleyman
Journal:  Am J Physiol Renal Physiol       Date:  2016-08-31

3.  Associations of epithelial sodium channel genes with blood pressure: the GenSalt study.

Authors:  F Liu; X Yang; X Mo; J Huang; J Chen; T N Kelly; J E Hixson; D C Rao; C C Gu; L C Shimmin; J Chen; T K Rice; J Li; K Schwander; J He; D-P Liu; D Gu
Journal:  J Hum Hypertens       Date:  2014-09-18       Impact factor: 3.012

4.  The Relationship between Single Nucleotide Polymorphisms in Taste Receptor Genes, Taste Function and Dietary Intake in Preschool-Aged Children and Adults in the Guelph Family Health Study.

Authors:  Elie Chamoun; Nicholas A Carroll; Lisa M Duizer; Wenjuan Qi; Zeny Feng; Gerarda Darlington; Alison M Duncan; Jess Haines; David W L Ma
Journal:  Nutrients       Date:  2018-07-29       Impact factor: 5.717

5.  A Novel Frameshift Mutation of SCNN1G Causing Liddle Syndrome with Normokalemia.

Authors:  Peng Fan; Yu-Mo Zhao; Di Zhang; Ying Liao; Kun-Qi Yang; Tao Tian; Ying Lou; Fang Luo; Wen-Jun Ma; Hui-Min Zhang; Lei Song; Jun Cai; Ya-Xin Liu; Xian-Liang Zhou
Journal:  Am J Hypertens       Date:  2019-07-17       Impact factor: 2.689

6.  Epac1-/- and Epac2-/- mice exhibit deficient epithelial Na+ channel regulation and impaired urinary Na+ conservation.

Authors:  Viktor N Tomilin; Kyrylo Pyrshev; Anna Stavniichuk; Naghmeh Hassanzadeh Khayyat; Guohui Ren; Oleg Zaika; Sherif Khedr; Alexander Staruschenko; Fang C Mei; Xiaodong Cheng; Oleh Pochynyuk
Journal:  JCI Insight       Date:  2022-02-08

7.  Landscape of Variability in Chemosensory Genes Associated With Dietary Preferences in Indian Population: Analysis of 1029 Indian Genomes.

Authors:  P Prakrithi; Pankaj Jha; Jushta Jaiswal; Disha Sharma; Rahul C Bhoyar; Abhinav Jain; Mohamed Imran; Vigneshwar Senthilvel; Mohit Kumar Divakar; Anushree Mishra; Vinod Scaria; Sridhar Sivasubbu; Mitali Mukerji
Journal:  Front Genet       Date:  2022-07-12       Impact factor: 4.772

8.  Association of Genetic Variation in the Epithelial Sodium Channel Gene with Urinary Sodium Excretion and Blood Pressure.

Authors:  Yoon Jung Yang; Jihye Kim; Chang Keun Kwock
Journal:  Nutrients       Date:  2018-05-14       Impact factor: 5.717
  8 in total

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