Boudewijn J M Braakhuis1, C René Leemans2, Otto Visser3. 1. Department of Otolaryngology-Head and Neck Surgery, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands. Electronic address: bjm.braakhuis@vumc.nl. 2. Department of Otolaryngology-Head and Neck Surgery, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands. 3. Department of Registration & Research, Comprehensive Cancer Center the Netherlands, PO Box 9236, 1006 AE Amsterdam, The Netherlands.
Abstract
BACKGROUND: Incidence and survival trends of head and neck squamous cell carcinoma (HNSCC) are essential knowledge for guiding policy making and research. METHODS: The total population of the Netherlands was studied covering 1989-2011. Two-and five-year survival and age-standardized incidence rates of HNSCC were assessed in relation to site, gender and age (15 years-of-age categories). RESULTS: We recorded a statistically significant increase of oral, oropharyngeal and hypopharyngeal carcinoma for males and females of all ages, varying from 0.6% (hypopharynx in males) to 2.7% (oropharynx in females) per year. The incidence of laryngeal carcinoma significantly decreased for males with 2.3% per year; for females the situation was stable. In young adults (below 45 years of age) the incidence figures were different: significant decreasing incidence trends were seen for both genders for carcinomas of the oropharynx, hypopharynx and larynx. Regarding oral carcinoma, no change was observed for the young patient group, but for subsites trends were divergent. Carcinoma of the floor or mouth decreased for both genders, but carcinoma of the tongue rose by a significant 2.8% per year for young males. Five-year survival trends for all ages showed no change for laryngeal carcinoma, a small improvement for oral and hypopharyngeal carcinoma, and a substantial and significant improvement of survival from 36% to 47% survival over the total period for oropharyngeal carcinoma. CONCLUSION: In the Netherlands for the last two decades, the incidence of oral, oropharyngeal and hypopharyngeal squamous cell carcinoma has increased and survival has improved. The incidence of laryngeal carcinoma has decreased in males, and remained unchanged in females; survival from laryngeal carcinoma has not changed.
BACKGROUND: Incidence and survival trends of head and neck squamous cell carcinoma (HNSCC) are essential knowledge for guiding policy making and research. METHODS: The total population of the Netherlands was studied covering 1989-2011. Two-and five-year survival and age-standardized incidence rates of HNSCC were assessed in relation to site, gender and age (15 years-of-age categories). RESULTS: We recorded a statistically significant increase of oral, oropharyngeal and hypopharyngeal carcinoma for males and females of all ages, varying from 0.6% (hypopharynx in males) to 2.7% (oropharynx in females) per year. The incidence of laryngeal carcinoma significantly decreased for males with 2.3% per year; for females the situation was stable. In young adults (below 45 years of age) the incidence figures were different: significant decreasing incidence trends were seen for both genders for carcinomas of the oropharynx, hypopharynx and larynx. Regarding oral carcinoma, no change was observed for the young patient group, but for subsites trends were divergent. Carcinoma of the floor or mouth decreased for both genders, but carcinoma of the tongue rose by a significant 2.8% per year for young males. Five-year survival trends for all ages showed no change for laryngeal carcinoma, a small improvement for oral and hypopharyngeal carcinoma, and a substantial and significant improvement of survival from 36% to 47% survival over the total period for oropharyngeal carcinoma. CONCLUSION: In the Netherlands for the last two decades, the incidence of oral, oropharyngeal and hypopharyngeal squamous cell carcinoma has increased and survival has improved. The incidence of laryngeal carcinoma has decreased in males, and remained unchanged in females; survival from laryngeal carcinoma has not changed.
Keywords:
Head and neck cancer; Head and neck squamous cell carcinoma (HNSCC); Hypopharyngeal cancer; Laryngeal cancer; Oral cancer; Oropharyngeal cancer
Authors: Martin L Read; Bhavika Modasia; Alice Fletcher; Rebecca J Thompson; Katie Brookes; Peter C Rae; Hannah R Nieto; Vikki L Poole; Sally Roberts; Moray J Campbell; Kristien Boelaert; Andrew S Turnell; Vicki E Smith; Hisham Mehanna; Christopher J McCabe Journal: Cancer Res Date: 2018-08-28 Impact factor: 12.701
Authors: Pierluigi Mariani; Diana Russo; Marco Maisto; Giuseppe Troiano; Vito Carlo Alberto Caponio; Marco Annunziata; Luigi Laino Journal: J Oral Pathol Med Date: 2021-12-09 Impact factor: 3.539
Authors: David S Lee; Ricardo J Ramirez; Jake J Lee; Carla V Valenzuela; Jose P Zevallos; Angela L Mazul; Sidharth V Puram; Michelle M Doering; Patrik Pipkorn; Ryan S Jackson Journal: Laryngoscope Date: 2020-12-02 Impact factor: 2.970