| Literature DB >> 24735046 |
Tian-Ze Li1, Xi-Bo Wang, Feng Sha, Xin-Yan Wu.
Abstract
The first organocatalytic enantioselective Mannich reaction of pyrazoleamides with isatin-derived N-Boc ketimines has been developed to afford 2-oxindole-based chiral β-amino amides in good yields (84-97%) with excellent diastereo- and enantioselectivities (up to 99:1 dr and >99% ee).Entities:
Year: 2014 PMID： 24735046 DOI： 10.1021/jo500145w
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354