Literature DB >> 24733892

Gq/5-HT2c receptor signals activate a local GABAergic inhibitory feedback circuit to modulate serotonergic firing and anxiety in mice.

Katharina Spoida1, Olivia A Masseck, Evan S Deneris, Stefan Herlitze.   

Abstract

Serotonin 2c receptors (5-HT2c-Rs) are drug targets for certain mental disorders, including schizophrenia, depression, and anxiety. 5-HT2c-Rs are expressed throughout the brain, making it difficult to link behavioral changes to circuit specific receptor expression. Various 5-HT-Rs, including 5-HT2c-Rs, are found in the dorsal raphe nucleus (DRN); however, the function of 5-HT2c-Rs and their influence on the serotonergic signals mediating mood disorders remain unclear. To investigate the role of 5-HT2c-Rs in the DRN in mice, we developed a melanopsin-based optogenetic probe for activation of Gq signals in cellular domains, where 5-HT2c-Rs are localized. Our results demonstrate that precise temporal control of Gq signals in 5-HT2c-R domains in GABAergic neurons upstream of 5-HT neurons provides negative feedback regulation of serotonergic firing to modulate anxiety-like behavior in mice.

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Year:  2014        PMID： 24733892      PMCID： PMC4035925          DOI： 10.1073/pnas.1321576111

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  23 in total

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Journal:  Brain Res Bull       Date:  1992-12       Impact factor: 4.077

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4.  Raphe serotonin neurons are not homogenous: electrophysiological, morphological and neurochemical evidence.

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Review 5.  Functional topography of midbrain and pontine serotonergic systems: implications for synaptic regulation of serotonergic circuits.

Authors:  Matthew W Hale; Christopher A Lowry
Journal:  Psychopharmacology (Berl)       Date:  2010-11-19       Impact factor: 4.530

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Journal:  Neuroscience       Date:  2003       Impact factor: 3.590

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Journal:  Behav Neurosci       Date:  1995-08       Impact factor: 1.912

10.  The dorsal raphe nucleus exerts opposed control on generalized anxiety and panic-related defensive responses in rats.

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Journal:  Behav Brain Res       Date:  2003-06-16       Impact factor: 3.332
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  33 in total

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Review 4.  Optogenetic approaches for dissecting neuromodulation and GPCR signaling in neural circuits.

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6.  Septal cholinergic neurons gate hippocampal output to entorhinal cortex via oriens lacunosum moleculare interneurons.

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7.  (S)-5-(2'-Fluorophenyl)-N,N-dimethyl-1,2,3,4-tetrahydronaphthalen-2-amine, a Serotonin Receptor Modulator, Possesses Anticonvulsant, Prosocial, and Anxiolytic-like Properties in an Fmr1 Knockout Mouse Model of Fragile X Syndrome and Autism Spectrum Disorder.

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8.  Constitutive activity of 5-HT2C receptors is present after incomplete spinal cord injury but is not modified after chronic SSRI or baclofen treatment.

Authors:  V M Tysseling; D A Klein; R Imhoff-Manuel; M Manuel; C J Heckman; M C Tresch
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9.  Activity of Raphé Serotonergic Neurons Controls Emotional Behaviors.

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10.  Ethanol induced adaptations in 5-HT2c receptor signaling in the bed nucleus of the stria terminalis: implications for anxiety during ethanol withdrawal.

Authors:  Catherine A Marcinkiewcz; Cayce E Dorrier; Alberto J Lopez; Thomas L Kash
Journal:  Neuropharmacology       Date:  2014-09-16       Impact factor: 5.250
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