Literature DB >> 24733458

Importance of multidrug efflux pumps in the antimicrobial resistance property of clinical multidrug-resistant isolates of Neisseria gonorrhoeae.

Daniel Golparian1, William M Shafer2, Makoto Ohnishi3, Magnus Unemo4.   

Abstract

The contribution of drug efflux pumps in clinical isolates of Neisseria gonorrhoeae that express extensively drug-resistant or multidrug-resistant phenotypes has heretofore not been examined. Accordingly, we assessed the effect on antimicrobial resistance of loss of the three gonococcal efflux pumps associated with a known capacity to export antimicrobials (MtrC-MtrD-MtrE, MacA-MacB, and NorM) in such clinical isolates. We report that the MIC of several antimicrobials, including seven previously and currently recommended for treatment was significantly impacted.
Copyright © 2014, American Society for Microbiology. All Rights Reserved.

Entities:  

Mesh：

Substances：

Year:  2014        PMID： 24733458      PMCID： PMC4068427          DOI： 10.1128/AAC.00038-14

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  37 in total

1.  Decreased azithromycin susceptibility of Neisseria gonorrhoeae due to mtrR mutations.

Authors:  L Zarantonelli; G Borthagaray; E H Lee; W M Shafer
Journal:  Antimicrob Agents Chemother       Date:  1999-10       Impact factor: 5.191

Review 2.  Inhibitors of efflux pumps in Gram-negative bacteria.

Authors:  Jean-Marie Pagès; Muriel Masi; Jacques Barbe
Journal:  Trends Mol Med       Date:  2005-08       Impact factor: 11.951

Review 3.  Practical applications and feasibility of efflux pump inhibitors in the clinic--a vision for applied use.

Authors:  Olga Lomovskaya; Keith A Bostian
Journal:  Biochem Pharmacol       Date:  2006-01-19       Impact factor: 5.858

Review 4.  Antibiotic efflux pumps in Gram-negative bacteria: the inhibitor response strategy.

Authors:  Abdallah Mahamoud; Jacqueline Chevalier; Sandrine Alibert-Franco; Winfried V Kern; Jean-Marie Pagès
Journal:  J Antimicrob Chemother       Date:  2007-01-17       Impact factor: 5.790

5.  Porin-mediated antibiotic resistance in Neisseria gonorrhoeae: ion, solute, and antibiotic permeation through PIB proteins with penB mutations.

Authors:  Melanie Olesky; Shuqing Zhao; Robert L Rosenberg; Robert A Nicholas
Journal:  J Bacteriol       Date:  2006-04       Impact factor: 3.490

6.  Modulation of Neisseria gonorrhoeae susceptibility to vertebrate antibacterial peptides due to a member of the resistance/nodulation/division efflux pump family.

Authors:  W M Shafer; X Qu; A J Waring; R I Lehrer
Journal:  Proc Natl Acad Sci U S A       Date:  1998-02-17       Impact factor: 11.205

7.  Loss-of-function mutations in the mtr efflux system of Neisseria gonorrhoeae.

Authors:  Wendy L Veal; Ansley Yellen; Jacqueline T Balthazar; Wubin Pan; Brian G Spratt; William M Shafer
Journal:  Microbiology (Reading)       Date:  1998-03       Impact factor: 2.777

8.  Transcriptional control of the mtr efflux system of Neisseria gonorrhoeae.

Authors:  K E Hagman; W M Shafer
Journal:  J Bacteriol       Date:  1995-07       Impact factor: 3.490

9.  Characterization of the MacA-MacB efflux system in Neisseria gonorrhoeae.

Authors:  Corinne E Rouquette-Loughlin; Jacqueline T Balthazar; William M Shafer
Journal:  J Antimicrob Chemother       Date:  2005-09-14       Impact factor: 5.790

10.  Resistance of Neisseria gonorrhoeae to antimicrobial hydrophobic agents is modulated by the mtrRCDE efflux system.

Authors:  K E Hagman; W Pan; B G Spratt; J T Balthazar; R C Judd; W M Shafer
Journal:  Microbiology       Date:  1995-03       Impact factor: 2.777
View more
  33 in total

Review 1.  Antimicrobial resistance in Neisseria gonorrhoeae in the 21st century: past, evolution, and future.

Authors:  Magnus Unemo; William M Shafer
Journal:  Clin Microbiol Rev       Date:  2014-07       Impact factor: 26.132

Review 2.  The challenge of efflux-mediated antibiotic resistance in Gram-negative bacteria.

Authors:  Xian-Zhi Li; Patrick Plésiat; Hiroshi Nikaido
Journal:  Clin Microbiol Rev       Date:  2015-04       Impact factor: 26.132

3.  In Vitro Activity of the Novel Pleuromutilin Lefamulin (BC-3781) and Effect of Efflux Pump Inactivation on Multidrug-Resistant and Extensively Drug-Resistant Neisseria gonorrhoeae.

Authors:  Susanne Jacobsson; Susanne Paukner; Daniel Golparian; Jörgen S Jensen; Magnus Unemo
Journal:  Antimicrob Agents Chemother       Date:  2017-10-24       Impact factor: 5.191

4.  High in vitro susceptibility to the novel spiropyrimidinetrione ETX0914 (AZD0914) among 873 contemporary clinical Neisseria gonorrhoeae isolates from 21 European countries from 2012 to 2014.

Authors:  Magnus Unemo; Johan Ringlander; Catherine Wiggins; Hans Fredlund; Susanne Jacobsson; Michelle Cole
Journal:  Antimicrob Agents Chemother       Date:  2015-06-15       Impact factor: 5.191

5.  Structure, Assembly, and Function of Tripartite Efflux and Type 1 Secretion Systems in Gram-Negative Bacteria.

Authors:  Ilyas Alav; Jessica Kobylka; Miriam S Kuth; Klaas M Pos; Martin Picard; Jessica M A Blair; Vassiliy N Bavro
Journal:  Chem Rev       Date:  2021-04-28       Impact factor: 60.622

Review 6.  Genomic sequencing of Neisseria gonorrhoeae to respond to the urgent threat of antimicrobial-resistant gonorrhea.

Authors:  A Jeanine Abrams; David L Trees
Journal:  Pathog Dis       Date:  2017-06-01       Impact factor: 3.166

7.  Quantitative Proteomics of the 2016 WHO Neisseria gonorrhoeae Reference Strains Surveys Vaccine Candidates and Antimicrobial Resistance Determinants.

Authors:  Fadi E El-Rami; Ryszard A Zielke; Teodora Wi; Aleksandra E Sikora; Magnus Unemo
Journal:  Mol Cell Proteomics       Date:  2018-10-23       Impact factor: 5.911

8.  In Vitro Activity of Delafloxacin against Clinical Neisseria gonorrhoeae Isolates and Selection of Gonococcal Delafloxacin Resistance.

Authors:  Olusegun O Soge; Stephen J Salipante; David No; Erin Duffy; Marilyn C Roberts
Journal:  Antimicrob Agents Chemother       Date:  2016-04-22       Impact factor: 5.191

Review 9.  The frontiers of addressing antibiotic resistance in Neisseria gonorrhoeae.

Authors:  Daniel H F Rubin; Jonathan D C Ross; Yonatan H Grad
Journal:  Transl Res       Date:  2020-02-29       Impact factor: 7.012

10.  cis- and trans-Acting Factors Influence Expression of the norM-Encoded Efflux Pump of Neisseria gonorrhoeae and Levels of Gonococcal Susceptibility to Substrate Antimicrobials.

Authors:  Corinne E Rouquette-Loughlin; Vijaya Dhulipala; Jennifer L Reimche; Erica Raterman; Afrin A Begum; Ann E Jerse; William M Shafer
Journal:  Antimicrob Agents Chemother       Date:  2018-07-27       Impact factor: 5.191
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.