Literature DB >> 2473319

Endothelin-1 participation in overt and inflammatory pain.

S H Ferreira1, M Romitelli, G de Nucci.   

Abstract

Endothelin-1 (ET-1) induced hyperalgesia in rats, abdominal constrictions in mice, incapacitation in dogs, and, when injected intradermally into humans, caused wheal and flare responses, which were accompanied by itching. The ET-1 induced constrictions in mice were prevented by indomethacin. In contrast, indomethacin had no effect on the hyperalgesic responses in the rat. These results indicate that ET-1 may play a role in modulating pain.

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Year:  1989        PMID： 2473319     DOI： 10.1097/00005344-198900135-00065

Source DB:  PubMed          Journal:  J Cardiovasc Pharmacol        ISSN： 0160-2446            Impact factor:   3.105


  50 in total

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